血清血管内皮生长因子/内皮抑素比值与儿童急性白血病的相关性

顾教伟,胡忠栋,刘壮

中国当代儿科杂志 ›› 2011, Vol. 13 ›› Issue (6) : 475-477.

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PDF(911 KB)
中国当代儿科杂志 ›› 2011, Vol. 13 ›› Issue (6) : 475-477.
论著·临床研究

血清血管内皮生长因子/内皮抑素比值与儿童急性白血病的相关性

  • 顾教伟,胡忠栋,刘壮
作者信息 +

Correlation between the ratio of serum vascular endothelial growth factor/endostatin and childhood acute leukemia

  • GU Jiao-Wei, HU Zhong-Dong, LIU Zhuang
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文章历史 +

摘要

目的:检测急性白血病(AL)患儿血清血管内皮生长因子(VEGF)、内皮抑素(ES)水平,探讨VEGF /ES (V/E) 比值与儿童AL的临床相关性。方法:采用酶联免疫双抗体夹心法检测35例AL患儿化疗前后血清VEGF、ES水平及V/E比值,并与30例健康儿童进行比较。结果:化疗前AL患儿血清中VEGF和ES水平分别为196±66 pg/mL和 31±7 ng/mL,显著高于对照组(29±10 pg/mL、19±4 ng/mL; P0.05)。35例AL患儿化疗前血清VEGF、V/E 比值与骨髓白血病细胞数呈正相关 (r=0.301和0.411,P<0.05)。结论:血清VEGF和ES与儿童AL的发生发展有关,V/E比值能更准确反映AL患儿疾病动态变化情况,有利于指导相关治疗。

Abstract

OBJECTIVE: To investigate the correlation between the ratio of serum vascular endothelial growth factor (VEGF)/endostatin (ES) and childhood acute leukemia(AL). METHODS: Serum levels of VEGF and ES were measured using ELISA in 35 children with acute AL before and after chemotherapy. The ratio of VEGF/ES was calculated. Thirty healthy children served as the control group. RESULTS: The serum levels of VEGF (196±66 pg/mL vs 29±10 pg/mL) and ES (35±7 ng/mL vs 19±4 ng/mL) in the AL group before chemotherapy were significantly higher than those in the control group (P<0.01). The ratio of VEGF/ES in the AL group before chemotherapy was significantly higher than that in the control group (6.7±3.0 vs 1.6±0.7; P<0.01). In 20 children with AL who achieved complete remission, the serum levels of VEGF and ES and the VEGF/ES ratio were reduced after chemotherapy (83±35 pg/mL, 27±5 ng/mL, 3.1±1.3, respectively; P<0.01), although the serum levels of VEGF and ES were still higher than those in the control group (P<0.01). The VEGF/ES ratio in CR patients was not significantly different from that in the control group. The serum levels of VEGF (r=0.301, P=0.045) and the VEGF/ES ratio (r=0.411, P=0.015) were positively correlated with the count of blast cells in juvenile bone marrow in 35 children with AL before chemotherapy. CONCLUSIONS: Serum VEGF and ES levels are associated with the development of childhood AL. The VEGF/ES ratio can be used to evaluate the disease progression in children with AL.

关键词

急性白血病 / 血管内皮生长因子/内皮抑素比值 / 儿童

Key words

Acute leukemia / Ratio of vascular endothelial growth factor/endostatin / Child

引用本文

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顾教伟,胡忠栋,刘壮. 血清血管内皮生长因子/内皮抑素比值与儿童急性白血病的相关性[J]. 中国当代儿科杂志. 2011, 13(6): 475-477
GU Jiao-Wei, HU Zhong-Dong, LIU Zhuang. Correlation between the ratio of serum vascular endothelial growth factor/endostatin and childhood acute leukemia[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(6): 475-477
中图分类号: R733   

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