目的：探讨血清铁蛋白与儿童注意缺陷多动障碍(ADHD)发生的关系。方法：利用计算机在万方数据库、中国全文期刊数据库、维普数据库和PubMed数据库中检索血清铁蛋白与儿童ADHD发生的相关文献，并应用RevMan 5.0软件对符合入选标准的文献进行异质性检验和效应值合并，同时进行敏感性分析和偏倚评估。结果：纳入符合条件的相关文献5篇，共计ADHD 258例，对照138例。血清铁蛋白与儿童ADHD发生关系的研究间存在异质性（P=0.003），采用随机效应模型进行分析,结果合并OR值（95%CI）为-23.09（-33.06～-13.13）， P＜0.00001。各研究的敏感性分析较稳定且无发表偏倚。结论：血清铁蛋白水平与儿童ADHD的发生有关。
Abstract
OBJECTIVE: To study the possible relationship between serum ferritin levels and susceptibility to attention deficit hyperactivity disorder (ADHD) in children. METHODS: The papers relating to the relationship between serum ferritin levels and susceptibility to childhood ADHD were searched in the Database CBM, CNKI, VIP and PubMed. The Meta-analysis software RevMan 5.0 was used for the heterogeneity test and for the pooled OR calculation. Sensitivity and publication bias analysis were performed. RESULTS: Five control studies were included for the Meta analysis, including 258 cases of ADHD and 138 control cases. There was heterogeneity in the studies on the relationship between serum ferritin levels and susceptibility to childhood ADHD (P=0.003). So the studies were analyzed using the random-effect model. The pooled OR of serum ferritin levels and susceptibility to childhood ADHD was -23.09 (95%CI:-33.06-13.13; P<0.00001). The funnel plots did not indicate the existence of publication bias. CONCLUSIONS: The results from present Meta analysis can prove that serum ferritin levels are associated with susceptibility to childhood ADHD.
关键词
铁蛋白 /
注意缺陷多动障碍 /
Meta分析 /
儿童
Key words
Ferritin /
Attention deficit hyperactivity disorder /
Meta analysis /
Child
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参考文献
［1］陈言钊，文飞球，周克英，杨春何，张蔚，李宁. 不同亚型注意力缺陷多动障碍患儿的临床特征分析［J］.中国当代儿科杂志，2010，12(9):704-708.
［2］崔继华，杨慧明.注意缺陷多动障碍患儿症状与血清铁蛋白之间的关系［J］.现代预防医学,2010,37(15):2828-2830.
［3］储晓彬，张瑜.儿童注意缺陷多动障碍与铁缺乏关系的研究［J］.南通大学学报（医学版）,2006,26（6）:492.
［4］GranthamMcGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children［J］. J Nutr, 2001, 131(2S-2): 649s-666s.
［5］陈燕惠，陈辉，刘艳艳，林桂秀，韦立新，陈丹玲.注意力缺陷多动障碍儿童下丘脑-垂体-肾上腺轴的功能研究［J］.中国当代儿科杂志,2009,11(12):992-995.
［6］Juneja M, Jain R, Singh V, Mallika V. Iron deficiency in Indian children with attention deficit hyperactivity disorder［J］. Indian Pediatr, 2010, 47(11): 955-958.
［7］Konofal E, Cortese S, Lecendreux M, Arnulf I, Mouren MC. Effectiveness of iron supplementation in a young child with attention-deficit/hyperactivity disorder［J］. Pediatrics, 2005, 116(5): e732-e734.
［8］Millichap JG, Yee MM, Davidson SI. Serum ferritin in children with attention-deficit hyperactivity disorder［J］. Pediatr Neurol, 2006, 34(3): 200-203.
［9］Oner O, Alkar OY, Oner P. Relation of ferritin levels with symptom ratings and cognitive performance in children with attention deficit-hyperactivity disorder［J］. Pediatr Int, 2008, 50(1): 40-44.
［10］Menegassi M, Mello ED, Guimar-es LR, Matte BC, Driemeier F, Pedroso GL, et al. Food intake and serum levels of iron in children and adolescents with attentiondeficit/hyperactivity disorder［J］. Rev Bras Psiquiatr, 2010, 32(2): 132-138.
［11］Volkow ND, Wang GJ, Newcorn J, Telang F, Solanto MV, Fowler JS, et al. Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder［J］. Arch Gen Psychiatry, 2007, 64(8): 932-940.
［12］李晓玲,王雪兰,黄丽丽.注意缺陷多动障碍与血清铁蛋白、血铅水平的相关性分析［J］.中国实用神经疾病杂志,2010,13(19): 9-11.
［13］Oner P, Oner O. Relationship of ferritin to symptom ratings children with attention deficit hyperactivity disorder: effect of comorbidity［J］. Child Psychiatry Hum Dev, 2008, 39(3): 323-330.
［14］Calarge C, Farmer C, DiSilvestro R, Arnold LE. Serum ferritin and amphetamine response in youth with attention-deficit/hyperactivity disorder［J］. J Child Adolesc Psychopharmacol, 2010, 20(6): 495-502.
［15］Dopheide JA, Pliszka SR. Attention-deficit-hyperactivity disorder: an update［J］. Pharmacotherapy, 2009, 29(6): 656-679.
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