儿童胃食管反流的食管外症状研究进展

张婷; 江米足

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中国当代儿科杂志 ›› 2012, Vol. 14 ›› Issue (5) : 391-395.

综述

儿童胃食管反流的食管外症状研究进展

张婷，江米足

作者信息 +

Advances in research on extra-oesophageal symptoms of pediatric gastroesophageal reflux

ZHANG Ting, JIANG Mi-Zu

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文章历史 +

摘要

儿童胃食管反流（GER）临床表现复杂多样，食管外症状是其重要的表现形式，包括与反流相关的呼吸道疾病、耳鼻咽喉部疾病、口腔疾病及神经精神症状等，其因果关系尚未能完全阐明。本文主要描述了GER与哮喘、慢性咳嗽、咽喉炎、喉乳头状瘤、鼻炎鼻窦炎、分泌性中耳炎、牙酸蚀症、明显生命危险事件、婴儿哭吵综合征等关系的研究进展，为儿童GER相关疾病的诊断和治疗提供新的思路。

Abstract

The manifestations of pediatric gastroesohageal reflux (GER) are varied and complex. Extra-oesophageal symptoms, including GER-related respiratory diseases, ear, nose and throat diseases, oral diseases and neuropsychiatric symptoms, are thought to be major manifestations of pediatric GER, but the causal relationship between GER and these extra-oesophageal symptoms is still unclear. Therefore, we describe the progress of reseach on the relationship between GER and asthma, chronic cough, laryngitis, pharyngitis, laryngeal papilloma, sinusitis, otitis media, dental erosion, apparent life-threatening event, and the crying baby syndrome in this review. It provides new strategies for the diagnosis and treatment of GER-related diseases in children.

Key words

Gastroesohageal reflux / Extra-oesophageal manifestations / Asthma / Sinusitis / Pharyngolaryngitis / Child

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张婷，江米足. 儿童胃食管反流的食管外症状研究进展[J]. 中国当代儿科杂志. 2012, 14(5): 391-395

ZHANG Ting, JIANG Mi-Zu. Advances in research on extra-oesophageal symptoms of pediatric gastroesophageal reflux[J]. Chinese Journal of Contemporary Pediatrics. 2012, 14(5): 391-395

中图分类号： R725.7

参考文献

［1］Suwandhi E, Ton MN, Schwarz SM. Gastroesophageal reflux in infancy and childhood［J］. Pediatr Ann, 2006, 35(4): 259-266.

［2］Megale SR, Scanavini AB, Andrade EC, Fernandes MI, Anselmo-Lima WT. Gastroesophageal reflux disease: its importance in ear, nose, and throat practice［J］. Int J Pediatr Otorhi Nolaryngd, 2006, 70(1): 81-88.

［3］Ruigómez A, Lundborg P, Johansson S, Wallander MA, García Rodríguez LA. Follow-up of a cohort of children and adolescents with gastro-esophageal reflux disease who were free of reflux esophagitis at initial diagnosis［J］. Scand J Gastroenterol, 2010, 45(7-8): 814-821.

［4］Canani RB, Cirillo P, Roggero P, Romano C, Malamisura B, Terrin G, et al. Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and communityacquired pneumonia in children［J］. Pediatrics, 2006, 117(5): e817-e820.

［5］Tolia V, Vandenplas Y. Systematic review: the extra-oesophageal symptoms of gastro-oesophageal reflux disease in children［J］. Aliment Pharm Ther, 2009, 29(3): 258-272.

［6］Vakil N, Van Zanten SV, Kahrilas P, Dent J, Jones R. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus［J］. Am J Gastroenterol, 2006, 101(8): 1900-1920.

［7］Lai YG, Wang ZG, Ji F, Wu JM, Chen X, Li Z, et al. Animal study for airway inflammation triggered by gastroesophageal reflux［J］. Chin Med J (Engl), 2009, 122(22): 2775-2778.

［8］Teixeira BC, Norton RC, Penna FJ, Carnargos PA, Lasmar LM, Macedo AV. Gastroesophageal reflux and asthma in childhood: a study on their relationship using esophageal pH monitoring［J］. J Pediatr (Rio J), 2007, 83(6): 535-540.

［9］Strdal K, Johannesdottir GB, Bentsen BS, Carlsen KC, Sandvik L. Asthma and overweight are associated with symptoms of gastro-oesophageal reflux［J］. Acta Paediatr, 2006, 95(10): 1197-1201.

［10］Szaflarska-Poplawska A, Poplawski C. Influence of gastroesophageal reflux measured by pH-impedance on asthma control degree in children and youth［J］. Prz Gastroenterol, 2011, 6(2): 110-117.

［11］Molle LD, Goldani HAS, Fagondes SC, Vieira VG, Barros SGS, Silva PS, et al. Nocturnal reflux in children and adolescents with persistent asthma and gastroesophageal reflux［J］. J Asthma, 2009, 46(4): 347-350.

［12］Kwiecien J, Machura E, Halkiewicz F, Karpe J. Clinical features of asthma in children differ with regard to the intensity of distal gastroesophageal acid reflux［J］. J Asthma, 2011, 48(4): 366-373.

［13］Lee SL, Shabatian H, Hsu JW, Applebaum H, Haigh PI. Hospital admissions for respiratory symptoms and failure to thrive before and after Nissen fundoplication［J］. J Pediatr Surg, 2008, 43(1): 5965.

［14］Thakkar K, Boatright RO, Gilger MA, El-Serag HB. Gastroesophageal reflux and asthma in children: A systematic review［J］. Pediatrics, 2010, 125(4): E925-E930.

［15］Stordal K, Johannesdottir GB, Bentsen BS, Knudsen PK, Carlsen KC, Closs O, et al. Acid suppression does not change respiratory symptoms in children with asthma and gastro-oesophageal reflux disease［J］. Arch Dis Child, 2005, 90(9): 956-960.

［16］Sopo SM, Radzik D, Calvani M. Does treatment with proton pump inhibitors for gastroesophageal reflux disease (GERD) improve asthma symptoms in children with asthma and GERD? A systematic review［J］. J Invest Allerg Clin, 2009, 19(1): 1-5.

［17］Yuksel H, Yilmaz O, Kirmaz C, Aydogdu S, Kasirga E. Frequency of gastroesophageal reflux disease in nonatopic children with asthma-like airway disease［J］. Resp Med, 2006, 100(3): 393-398.

［18］Borrelli O, Marabotto C, Mancini V, Aloi M, Macri F, Falconieri P, et al. Role of gastroesophageal reflux in children with unexplained chronic cough［J］. J Pediatr Gastr Nutr, 2011, 53(3): 287-292.

［19］Sifrim D, Dupont L, Blondeau K, Zhang X, Tack J, Janssens J. Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring［J］. Gut, 2005, 54(4): 449-454.

［20］Marchant JM, Masters IB, Taylor SM, Cox NC, Seymour GJ, Chang AB. Evaluation and outcome of young children with chronic cough［J］. Chest, 2006, 129(5): 1132-1141.

［21］Blondeau K, Mertens V, Dupont L, Pauwels A, Farre R, Malfroot A, et al. The relationship between gastroesophageal reflux and cough in children with chronic unexplained cough using combined impedance-pH-manometry recordings［J］. Pediatr Pulm, 2011, 46(3): 286-294.

［22］Chang AB, Lasserson TJ, Gaffney J, Connor Fl, Garske LA. Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults［J/OL］. Cochrane Db Syst Rev, 2011,19(1): CD004823.

［23］Habesoglu M, Habesoglu TE, Gunes P, Kinis V, Toros SZ, Eriman M, et al. How does reflux affect laryngeal tissue quality? An experimental and histopathologic animal study［J］. Otolaryng Head Neck, 2010, 143(6): 760-764.

［24］Salminen P, Karvonen J, Ovaska J. Long-term outcomes after laparoscopic nissen fundoplication for reflux laryngitis［J］. Digest Surg, 2010, 27(6): 509-514.

［25］Toros SZ, Toros AB, Yueksel OD, Ozel L, Akkaynak C, Naiboglu B. Association of laryngopharyngeal manifestations and gatroesophageal reflux［J］. Eur Arch Otorhinolaryngol, 2009, 266(3): 403-409.

［26］Noordzij JP, Khidr A, Evans BA, Desper E, Mittal RK, Reibel JF, et al. Evaluation of omeprazole in the treatment of reflux laryngitis: a prospective, placebo-controlled, randomized, double-blind study［J］. Laryngoscope, 2001, 111(12): 2147-2151.

［27］Eherer AJ, Habermann W, Hammer HF, Kiesler K, Friedrich G, Krejs GJ. Effect of pantoprazole on the course of reflux-associated laryngitis: a placebo-controlled doubleblind crossover study［J］. Scand J Gastroenterol, 2003, 38(5): 462-467.

［28］Mckenna M, Brodsky L. Extraesophageal acid reflux and recurrent respiratory papilloma in children［J］. Int J Pediatr Otorhi nolaryngol, 2005, 69(5): 597-605.

［29］Pignatari SS, Liriano RY, Avelino MA, Testa JR, Fujita R, De Marco EK. Gastroesophageal reflux in patients with recurrent laryngeal papillomatosis［J］. Braz J Otorhinolaryngol, 2007, 73(2): 210-214.

［30］Kotsis GP, Nikolopoulos TP, Yiotakis IE, Papacharalampous GX, Kandiloros DC. Recurrent acute otitis media and gastroesophageal reflux disease in children. Is there an association?［J］. Int J Pediatr Otorhi, 2009, 73(10): 1373-1380.

［31］Tasker A, Dettmar PW, Panetti M, Koufman JA, Birchall JP, Pearson JP. Reflux of gastric juice and glue ear in children［J］. Lancet, 2002, 359(9305): 493-493.

［32］Crapko M, Kerschner JE, Syring M, Johnston N. Role of extra-esophageal reflux in chronic otitis media with effusion［J］. Laryngoscope, 2007, 117(8): 1419-1423.

［33］Sudhoff H, Bucker R, Groll C, Shagdarsuren S, Dazert S, Schreiber S. Tracing of gastric reflux into the middle ear in a Mongolian gerbil model［J］. Otol Neurotol, 2007, 28(1): 124-128.

［34］Klokkenburg JJC, Hoeve HLJ, Francke J, Wieringa MH, Borgstein J, Feenstra L. Bile acids identified in middle ear effusions of children with otitis media with effusion［J］. Laryngoscope, 2009, 119(2): 396-400.

［35］Karkos PD, Assimakopoulos D, Issing WJ. Pediatric middle ear infections and gastroesophageal reflux［J］. Int J Pediatr Otorhi, 2004, 68(12): 1489-1492.

［36］Phipps CD, Wood WE, Gibson WS, Cochran WJ. Gastroesophageal reflux contributing to chronic sinus disease in children: a prospective analysis［J］. Arch Otolaryngol Head Neck Surg, 2000, 126(7): 831-836.

［37］Pinto JM, Baroody FM. Chronic sinusitis and allergic rhinitis: at the nexus of sinonasal inflammatory disease［J］. J Otolaryngol, 2002, 31 (Suppl 1): S10-S17.

［38］Contencin P, Narcy P. Nasopharyngeal pH monitoring in infants and children with chronic rhinopharyngitis［J］. Int J Pediatr Otorhi, 1991, 22(3): 249-256.

［39］Delgaudio JM. Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis［J］. Laryngoscope, 2005, 115(6): 946-957.

［40］Linnett V, Seow WK, Connor F, Shepherd R. Oral health of children with gastro-esophageal reflux disease: A controlled study［J］. Aust Dent J, 2002, 47(2): 156-162.

［41］Holbrook WP, Furuholm J, Gudmundsson K, Theodors A, Meurman JH. Gastric reflux is a significant causative factor of tooth erosion［J］. J Dent Res, 2009, 88(5): 422-426.

［42］Wilder-Smith CH, Wilder-Smith P, Kawakami-Wong H, Voronets J, Osann K, Lussi A. Quantification of dental erosions in patients with GERD using optical coherence tomography before and after double-blind, randomized treatment with esomeprazole or placebo［J］. Am J Gastroenterol, 2009, 104(11): 2788-2795.

［43］Semeniuk J, Kaczmarski M, Wasilewska J, Nowowiejska B. Is acid gastroesophageal reflux in children with ALTE etiopathogenetic factor of life threatening symptoms?［J］. Adv Med Sci, 2007, 52: 213-221.

［44］Maggio ABR, Schappi MG, Benkebil F, Posfay-Barbe KM, Belli DC. Increased incidence of apparently life-threatening events due to supine position［J］. Paediatr Perinat Ep, 2006, 20(6): 491-496.

［45］Valusek PA, St Peter SD, Tsao K, Spilde TI, Ostlie DJ, Holcomb GW. The use of fundoplication for prevention of apparent life-threatening events［J］. J Pediatr Surg, 2007, 42(6): 1022-1025.

［46］Rao MR, Brenner RA, Schisterman EF, Vik T, Mills JL. Long term cognitive development in children with prolonged crying［J］. Arch Dis Child, 2004, 89(11): 989-992.

［47］Reijneveld SA, Lanting CI, Crone MR,Van Wouwe JP. Exposure to tobacco smoke and infant crying［J］. Acta Paediatr, 2005, 94(2): 217-221.

［48］Vandenplas Y, Koletzko S, Isolauri E, Hill D, Oranje AP, Brueton M, et al. Guidelines for the diagnosis and management of cow's milk protein allergy in infants［J］. Arch Dis Child, 2007, 92(10): 902-908.

［49］Nielsen RG, Bindslev-Jensen C, Kruse-Andersen S,Husby S. Severe gastroesophageal reflux disease and cow milk hypersensitivity in infants and children: disease association and evaluation of a new challenge procedure［J］. J Pediatr Gastroenterol Nutr, 2004, 39(4): 383-391.

［50］Heine RG, Jordan B, Lubitz L, Meehan M, Catto-Smith AG. Clinical predictors of pathological gastro-oesophageal reflux in infants with persistent distress［J］. J Paediatr Child Health, 2006, 42(3): 134-139.

［51］Vandenplas Y, Badriul H, Verghote M, Hauser B,Kaufman L. Oesophageal pH monitoring and reflux oesophagitis in irritable infants［J］. Eur J Pediatr, 2004, 163(6): 300-304.

［52］Orenstein SR, Shalaby TM, Devandry SN, Liacouras CA, Czinn SJ, Dice JE, et al. Famotidine for infant gastro-oesophageal reflux: a multi-centre, randomized, placebocontrolled, withdrawal trial［J］. Aliment Pharmacol Ther, 2003, 17(9): 1097-1107.

［53］Orenstein SR, Hassall E, Furmaga-Jablonska W, Atkinson S, Raanan M. Multicenter, double-blind, randomized, placebo-controlled trial assessing the efficacy and safety of proton pump inhibitor lansoprazole in infants with symptoms of gastroesophageal reflux disease［J］. J Pediatr, 2009, 154(4):514-520.

［54］Jordan B, Heine RG, Meehan M, Catto-Smith AG, Lubitz L. Effect of antireflux medication, placebo and infant mental health intervention on persistent crying: a randomized clinical trial［J］. J Paediatr Child Health, 2006, 42(1-2):49-58.

［55］Bharwani S. Gastroesophageal reflux disease (GERD) in children: from infancy to adolescence［J］. J Med Sci, 2011, 4(1): 25-39