以脓毒症起病的儿童噬血细胞性淋巴组织细胞增生症6例分析

郝小生, 王翠英, 陈银波

中国当代儿科杂志 ›› 2015, Vol. 17 ›› Issue (12) : 1360-1362.

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中国当代儿科杂志 ›› 2015, Vol. 17 ›› Issue (12) : 1360-1362. DOI: 10.7499/j.issn.1008-8830.2015.12.020
临床经验

以脓毒症起病的儿童噬血细胞性淋巴组织细胞增生症6例分析

  • 郝小生, 王翠英, 陈银波
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Hemophagocytic lymphohistiocytosis manifesting as sepsis in children:a report of 6 cases

  • HAO Xiao-Sheng, WANG Cui-Ying, CHEN Yin-Bo
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郝小生, 王翠英, 陈银波. 以脓毒症起病的儿童噬血细胞性淋巴组织细胞增生症6例分析[J]. 中国当代儿科杂志. 2015, 17(12): 1360-1362 https://doi.org/10.7499/j.issn.1008-8830.2015.12.020
HAO Xiao-Sheng, WANG Cui-Ying, CHEN Yin-Bo. Hemophagocytic lymphohistiocytosis manifesting as sepsis in children:a report of 6 cases[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(12): 1360-1362 https://doi.org/10.7499/j.issn.1008-8830.2015.12.020

参考文献

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[3] Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign:international guidelines for management of severe sepsis and septic shock:2012[J]. Crit Care Med, 2013, 41(2): 580-637.
[4] Raschke RA, Garcia-Orr R.Hemophagocytic lymphohistiocytosis:a potentially underrecognized association with systemic inflammatory response syndrome, severe sepsis, and septic shock in adults[J]. Chest, 2011, 140(4):933-938.
[5] Niece JA, Rogers ZR, Ahmad N, et al. Hemophagocytic lymphohistiocytosis in Texas:observations on ethnicity and race[J]. Pediatr Blood Cancer, 2010, 54(3):424-428.
[6] de Saint Basile G, Ménasché G, Fischer A. Molecular mechanisms of biogenesis and exocytosis of cytotoxic granuules[J]. Nat Rev Immunol, 2010, 10(8):568-579.
[7] Hall MW, Knatz NL, Vetterly C, et al. Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome[J]. Intensive Care Med, 2011, 37(3):525-532.
[8] 汤永民. "噬血细胞性淋巴组织细胞增生症诊疗建议"解读[J]. 中华儿科杂志, 2012, 50(11):826-828.
[9] Allen CE, Yu X, Kozinetz CA, et al. Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis[J]. Pediatr Blood Cancer, 2008, 50(6): 1227-1235.
[10] Xu XJ, Tang YM, Song H, et al. Diagnostic accuracy of a specific cytokine pattern in hemophagocytic lymphohistiocytosis in children[J]. J Pediatr, 2012,160(6):984-990.e1.
[11] Tang YM,Xu XJ.Advances in hemophagocytic lymphohistiocytosis:pathogenesis, early diagnosis/differential diagnosis, and treatment[J]. Sci World J, 2011, 11:697-708.
[12] Usmani GN, Woda BA, Newburger PE. Advances in understanding the pathogenesis of HLH[J]. Br J Haematol, 2013, 161(5):609-622.
[13] 张景荣, 梁筱灵, 靳蓉, 等. HLH-2004方案诊治儿童噬血细胞综合征临床分析[J]. 中国当代儿科杂志, 2013, 15(8):686-688.
[14] Li F, Yang Y, Jin F, et al. Clinical characteristics and prognostic factors of adult hemophagocytic syndrome patients:a retrospective study of increasing awareness of a disease from a single-center in China[J]. Orphanet J Rare Dis, 2015, 10(1):20.

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