中国当代儿科杂志
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CN 43-1301/R
 
中国当代儿科杂志  2018, Vol. 20 Issue (7): 554-558    DOI:10.7499/j.issn.1008-8830.2018.07.008
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HCMV感染患儿HLA-DR、CD4+CD25+调节性T细胞及IL-17、IL-27表达水平与肝损害的相关性研究
朱莉莉, 徐玲, 王军
徐州医科大学附属医院儿科, 江苏 徐州 221000
Relationship between expression of peripheral blood HLA-DR, CD4+CD25+ regulatory T cells, IL-17 and IL-27 with liver damage in children with human cytomegalovrius infection
ZHU Li-Li, XU Ling, WANG Jun
Department of Pediatrics, Affliated Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221000, China
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摘要 

目的 探讨人巨细胞病毒(HCMV)感染患儿HLA-DR、CD4+CD25+调节性T细胞(CD4+CD25+Treg)以及IL-17、IL-27的表达水平与肝功能损害的相关性。方法 以21例HCMV感染肝功能损害患儿和21例HCMV感染非肝功能损害患儿为研究对象。流式细胞术检测两组外周血CD4+CD25+Treg、HLA-DR细胞的表达;ELISA检测血浆IL-17及IL-27表达。结果 与非肝损组比较,肝损组患儿CD4+CD25+Treg比率较低,IL-17、IL-27表达水平较高,差异均有统计学意义(P < 0.05)。IL-17及IL-27水平与CD4+CD25+Treg细胞比率呈负相关(P < 0.01)。结论 CD4+CD25+Treg细胞介导的免疫耐受失衡及IL-17、IL-27等炎症因子过度激活可能参与HCMV感染肝功能损害发生。

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朱莉莉
徐玲
王军
关键词 人巨细胞病毒肝功能损害CD4+CD25+调节性T细胞HLA-DR炎症因子儿童    
Abstract:Objective To study the relationship between the expression of peripheral blood HLA-DR, CD4+ CD25+ regulatory T cells, IL-17 and IL-27 with liver damage in children with human cytomegalovirus (HCMV) infection.Methods Twenty-one HCMV children with liver damage and twenty-one HCMV children without liver damage were enrolled in this study. The expression of peripheral blood HLA-DR and CD4+ CD25+ regulatory T cells was detected by flow cytometry. Plasma levels of IL-17 and IL-27 were measured using ELISA.Results The plasma levels of IL-17 and IL-27 in children with liver damage were significantly higher than in those without liver damage, while the expression of peripheral blood CD4+ CD25+ regulatory T cells was lower than in those without liver damage (P < 0.05). Plasma IL-17 and IL-27 levels were negatively correlated with the expression of peripheral blood CD4+ CD25+ regulatory T cells (P < 0.01).Conclusions Immune imbalance mediated by CD4+ CD25+ regulatory T cells and over-expression of IL-17 and IL-27 may be involved in the pathogenesis of liver damage in children with HCMV infection.
Key wordsHuman cytomegalovirus    Liver damage    CD4+CD25+ regulatory T cell    HLA-DR    Inflammatory factor    Child   
收稿日期: 2018-02-22     
基金资助:江苏省六大人才高峰资助项目[2011-WS-075]。
通讯作者: 王军,男,主任医师,教授。Email:woyouyigelianai12@163.com     E-mail: woyouyigelianai12@163.com
作者简介: 朱莉莉,女,硕士研究生。
引用本文:   
朱莉莉,徐玲,王军. HCMV感染患儿HLA-DR、CD4+CD25+调节性T细胞及IL-17、IL-27表达水平与肝损害的相关性研究[J]. 中国当代儿科杂志, 2018, 20(7): 554-558.
ZHU Li-Li,XU Ling,WANG Jun. Relationship between expression of peripheral blood HLA-DR, CD4+CD25+ regulatory T cells, IL-17 and IL-27 with liver damage in children with human cytomegalovrius infection[J]. CJCP, 2018, 20(7): 554-558.
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