OBJECTIVE:To study the effect of early nutrition on the development of physique and small intestine in rats with intrauterine growth retardation (IUGR). METHODS: Eight normal pubs fed with normal protein diet (20%) were used as normal controls. The IUGR pups were assigned into normal protein diet group (IC group), low protein diet group (IL group) and high protein diet group (IH group). On the 1st, 21st and 28th day after birth respectively, the weight and length of small intestine (SI), the body weight and length, and the activities of disaccharidase were measured. RESULTS: The body weight and length, weight and length of SI in rats with IUGR at birth were all significantly lower than those in normal rats (P< 0.05 ). Body length, body weight, length and weight of SI in IL group were all lower than those in IC, IH and normal control groups in the first 4 weeks after birth. The physique and small intestine in IH group caught up growth quickly, the body weight in the 4th week reached the normal value. In the third week, the lactase activity in IL and IH groups were higher than that in normal control group (P< 0.05 ). In the 4th week, the sucrase activity in IL group was lower than that in normal control (P< 0.05 ). CONCLUSIONS: Early nutrition after birth has an important effect on the development of physique and SI in rats with IUGR."/>
早期营养干预对宫内生长迟缓大鼠小肠发育及体格生长的影响(英文)
Abstract：OBJECTIVE:To study the effect of early nutrition on the development of physique and small intestine in rats with intrauterine growth retardation (IUGR). METHODS: Eight normal pubs fed with normal protein diet (20%) were used as normal controls. The IUGR pups were assigned into normal protein diet group (IC group), low protein diet group (IL group) and high protein diet group (IH group). On the 1st, 21st and 28th day after birth respectively, the weight and length of small intestine (SI), the body weight and length, and the activities of disaccharidase were measured. RESULTS: The body weight and length, weight and length of SI in rats with IUGR at birth were all significantly lower than those in normal rats (P< 0.05 ). Body length, body weight, length and weight of SI in IL group were all lower than those in IC, IH and normal control groups in the first 4 weeks after birth. The physique and small intestine in IH group caught up growth quickly, the body weight in the 4th week reached the normal value. In the third week, the lactase activity in IL and IH groups were higher than that in normal control group (P< 0.05 ). In the 4th week, the sucrase activity in IL group was lower than that in normal control (P< 0.05 ). CONCLUSIONS: Early nutrition after birth has an important effect on the development of physique and SI in rats with IUGR.
DENG Hui-Ying,QIU Xiao-Shan. Effects of Early Nutrition After Birth on theDevelopment of Small Intestine and Body Growth in Rats with Intrauterine Growth Retardation[J]. CJCP, 2003, 5(3): 197-200.
