OBJECTIVE: To study the characteristics of brain damages in utero in order to establish more effective treatment. METHODS: Clinical data of 115 neonates with brain damages which developed in utero were studied retrospectively: types of brain damages, high risk factors associated with brain damages, relationship between the degree of brain damages and high risk factors and neurological signs. Follow up was done to observe the prognosis in survivals. RESULTS: Of the 115 patients, 71 ( 61.7% ) had intracranial hemorrhage and 44 ( 38.3% ) showed cerebral parenchyma lesions; 64 ( 55.6% ) had high risk factors associated with brain damages; 34 ( 29.6% ) had abnormal neurological signs: convulsion, hypertonia or irritability. The degree of brain damages was correlated with the high risk factors and neonatal neurological signs. Of the 55 follow up patients, 16 ( 29.1% ) had neurological sequels. CONCLUSIONS: It is necessary to understand the characteristics of brain damages which develop in utero to enable early diagnosis and intervention and to improve the survival rate and prognosis."/>
胎儿期脑损伤的发生与预后研究
Abstract：OBJECTIVE: To study the characteristics of brain damages in utero in order to establish more effective treatment. METHODS: Clinical data of 115 neonates with brain damages which developed in utero were studied retrospectively: types of brain damages, high risk factors associated with brain damages, relationship between the degree of brain damages and high risk factors and neurological signs. Follow up was done to observe the prognosis in survivals. RESULTS: Of the 115 patients, 71 ( 61.7% ) had intracranial hemorrhage and 44 ( 38.3% ) showed cerebral parenchyma lesions; 64 ( 55.6% ) had high risk factors associated with brain damages; 34 ( 29.6% ) had abnormal neurological signs: convulsion, hypertonia or irritability. The degree of brain damages was correlated with the high risk factors and neonatal neurological signs. Of the 55 follow up patients, 16 ( 29.1% ) had neurological sequels. CONCLUSIONS: It is necessary to understand the characteristics of brain damages which develop in utero to enable early diagnosis and intervention and to improve the survival rate and prognosis.
