Abstract：Objective To inverstigate the changes of serum electrolytes and osmolality in the neonates with hypoxic ischaemic encephalophathy (HIE). Methods Serum levels of sodium [Na +], potassium [K +], chloride [Cl -], ionized calcium [Ca 2+ ], and osmolality were determined in 120 neonates with HIE and in 32 normal neonates. Results In all neonates with HIE (mild, moderate and severe), the serum levels of [Na +] ( 130.2 ± 6.0 ) mmol/L, ( 126.3 ± 9.1 ) mmol/L, ( 121.2 ± 12.2 ) mmol/L respectively; [Ca 2+ ] ( 1.0 ± 0.2 ) mmol/L, ( 0.9 ± 0.2 ) mmol/L, ( 0.8 ± 0.2 ) mmol/L respectively and osmolality ( 256.7 ± 11.2 ) mOsm/L, ( 248.7 ± 21.3 ) mOsm/L, ( 241.1 ± 22.2 ) mOsm/L respectively were lower than those in nomal neonates ( 136.1 ± 1.1 ) mmol/L, ( 1.2 ± 0.1 ) mmol/L, ( 262.6 ± 8.8 ) mOsm/L respectively, wheares serum [K +] levels were higher. Serum [Cl -] levels in the moderate and serere HIE neonates were lower compared with normal neonates. Serum levels of [Na +] and [Ca 2+ ] in the dead neonates were significantly decreased and obstinate; and osmolar gap was more than 10 mOsm/L. Conclusions Hyponatremia, hypocalcemia, and serum low osmolality occur in neonates with HIE and may be of prognostic significance.
ZHANG Ning,XIAO Xin,LV Hui. Changges of Serum Electrolytes and Osmolality in Neonates with Hypoxic-Ischaemic Encephalophathy[J]. CJCP, 2000, 2(3): 158-161.
