Current status of the application of 1H-magnetic resonance spectroscopy in neonates with hypoxic-ischemic encephalopathy
ZOU Rong, TANG Jun, BAO Shan, WU Tian, HUANG Jing-Lan, QU Yi, MU De-Zhi
Department of Pediatrics, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University), Ministry of Education, Chengdu 610041, China
Abstract：Objective To investigate the current status of the application of 1H-magnetic resonance spectroscopy (1H-MRS) in neonates with hypoxic-ischemic encephalopathy (HIE), and to describe the trend of research in the field. Methods PubMed, EMBASE, and Web of Science were searched for English articles published up to January 10, 2018, with the combination of key words and MeSH terms. The articles were screened according to inclusion and exclusion criteria. Excel 2016, Bicomb 2.0, and VOSviewer1.6.6 were used to analyze the key words, to perform a cluster analysis of hot words, and to plot the knowledge map. Results A total of 66 articles were included, and 27 high-frequency key words were extracted. The results showed that 1H-MRS was mainly used in four directions of the clinical practice and scientific research on HIE. In clinical practice, 1H-MRS attracted wide attention as a clinical examination for HIE and a tool for prognostic evaluation; in scientific research, 1H-MRS was used in animal experiments and studies associated with mild hypothermia therapy. Conclusions As an auxiliary means of magnetic resonance imaging, 1H-MRS plays an important role in investigating the pathogenesis of neonatal HIE, improving existing therapies, and evaluating the prognosis of neonates with HIE.
ZOU Rong,TANG Jun,BAO Shan et al. Current status of the application of 1H-magnetic resonance spectroscopy in neonates with hypoxic-ischemic encephalopathy[J]. CJCP, 2018, 20(6): 449-455.
Volpe JJ. Neonatal encephalopathy:an inadequate term for hypoxic-ischemic encephalopathy[J]. Ann Neurol, 2012, 72(2):156-166.
[2]
Bonifacio SL, Devries LS, Groenendaal F. Impact of hypothermia on predictors of poor outcome:how do we decide to redirect care?[J]. Semin Fetal Neonatal Med, 2015, 20(2):122-127.
[3]
Ment LR, Bada HS, Barnes P, et al. Practice parameter:neuroimaging of the neonate:report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society[J]. Neurology, 2002, 58(12):1726-1738.
[4]
Cheong JL, Coleman L, Hunt RW, et al. Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy:substudy of a randomized trial[J]. Arch Pediatr Adolesc Med, 2012, 166(7):634-640.
[5]
Ghei SK, Zan E, Nathan JE, et al. MR imaging of hypoxic-ischemic injury in term neonates:pearls and pitfalls[J]. Radiographics, 2014, 34(4):1047-1061.
[6]
Thayyil S, Chandrasekaran M, Taylor A, et al. Cerebral magnetic resonance biomarkers in neonatal encephalopathy:a meta-analysis[J]. Pediatrics, 2010, 125(2):e382-e395.
[7]
Dabi Y, Darrigues L, Katsahian S, et al. Publication trends in bariatric surgery:a bibliometric study[J]. Obes Surg, 2016, 26(11):2691-2699.
Wang Y, Wang Q, Wei X, et al. Global scientific trends on exosome research during 2007-2016:a bibliometric analysis[J]. Oncotarget, 2017, 8(29):48460-48470.
Khalil GM, Gotway Crawford CA. A bibliometric analysis of U.S.-based research on the Behavioral Risk Factor Surveillance System[J]. Am J Prev Med, 2015, 48(1):50-57.
Cheong JL, Cady EB, Penrice J, et al. Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury:metabolite peak-area ratios, relaxation times, and absolute concentrations[J]. AJNR Am J Neuroradiol, 2006, 27(7):1546-1554.
[15]
Sijens PE, Wischniowsky K, Ter Horst HJ. The prognostic value of proton magnetic resonance spectroscopy in term newborns treated with therapeutic hypothermia following asphyxia[J]. Magn Reson Imaging, 2017, 42:82-87.
[16]
Robertson NJ, Thayyil S, Cady EB, et al. Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy:from neuropathological correlates to future clinical applications[J]. Curr Pediatr Rev, 2014, 10(1):37-47.
[17]
Alderliesten T, De Vries LS, Staats L, et al. MRI and spectroscopy in (near) term neonates with perinatal asphyxia and therapeutic hypothermia[J]. Arch Dis Child Fetal Neonatal Ed, 2017, 102(2):F147-F152.
[18]
Ancora G, Testa C, Grandi S, et al. Prognostic value of brain proton MR spectroscopy and diffusion tensor imaging in newborns with hypoxic-ischemic encephalopathy treated by brain cooling[J]. Neuroradiology, 2013, 55(8):1017-1025.
[19]
van Doormaal PJ, Meiners LC, ter Horst HJ, et al. The prognostic value of multivoxel magnetic resonance spectroscopy determined metabolite levels in white and grey matter brain tissue for adverse outcome in term newborns following perinatal asphyxia[J]. Eur Radiol, 2012, 22(4):772-778.
[20]
Alderliesten T, de Vries LS, Benders M, et al. MR imaging and outcome of term neonates with perinatal asphyxia:value of diffusion-weighted MR imaging and 1H MR spectroscopy[J]. Radiology, 2011, 261(1):235-242.
[21]
Ancora G, Soffritti S, Lodi R, et al. A combined a-EEG and MR spectroscopy study in term newborns with hypoxic-ischemic encephalopathy[J]. Brain Dev, 2010, 32(10):835-842.
[22]
Berger HR, Brekke E, Wideroe M, et al. Neuroprotective treatments after perinatal hypoxic-ischemic brain injury evaluated with Magnetic Resonance Spectroscopy[J]. Dev Neurosci, 2017, 39(1-4):36-48.
[23]
Azzopardi D, Edwards AD. Magnetic resonance biomarkers of neuroprotective effects in infants with hypoxic ischemic encephalopathy[J]. Semin Fetal Neonatal Med, 2010, 15(5):261-269.
[24]
Pound P, Ebrahim S, Sandercock P, et al. Where is the evidence that animal research benefits humans?[J]. BMJ, 2004, 328(7438):514-517.
[25]
Gunn AJ, Laptook AR, Robertson NJ, et al. Therapeutic hypothermia translates from ancient history in to practice[J]. Pediatr Res, 2017, 81(1-2):202-209.
[26]
Wisnowski JL, Wu TW, Reitman AJ, et al. The effects of therapeutic hypothermia on cerebral metabolism in neonates with hypoxic-ischemic encephalopathy:an in vivo 1H-MR spectroscopy study[J]. J Cereb Blood Flow Metab, 2016, 36(6):1075-1086.
[27]
Owji ZP, Gilbert G, Saint-Martin C, et al. Brain temperature is increased during the first days of life in asphyxiated newborns:developing brain injury despite hypothermia treatment[J]. AJNR Am J Neuroradiol, 2017, 38(11):2180-2186.
[28]
Wu TW, Mclean C, Friedlich P, et al. Brain temperature in neonates with hypoxic-ischemic encephalopathy during therapeutic hypothermia[J]. J Pediatr, 2014, 165(6):1129-1134.
[29]
Berger HR, Nyman A, Morken TS, et al. Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo 1H MR spectroscopy[J]. PLoS One, 2017, 12(9):e185202.
[30]
Azzopardi D, Robertson NJ, Bainbridge A, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe):a proof-of-concept, open-label, randomised controlled trial[J]. Lancet Neurol, 2016, 15(2):145-153.
