Abstract：Objective To asses the effect of anticholinergic agent on the treatment of child asthma and to study the changes in peak expiratory flow rate (PEFR). Methods In the treatment group ipratropium bromide and salbutamol were combined to treat asthmatic children suffering from an acute attack (n=11), while in the control group only salbutamol by inhalation was used (n=9). The changes in PEFR ipratropium were measured. Results After the administration of ipratropium bromide to the treatment group, the percentage of seperately measured PEFR compared to the predicted PEFR were 68.8±5.6%, 72.0±3.4% and 71.1±3.7% after 40, 60 and 80 minutes, respectively. However, the percentages of the control group were 60.6±5.7%, 60.8±6.3% and 59.1 ± 6.7% . There was a significant difference between the two groups (P<0.01). Conclusions Combined ipratropium bromide and salbutamol by inhalation in the treatment of child asthma results in significant improvement in pulmonary function, longer lasting time of bronchodilatory effect and less side effect than salbutamol alone.
DAI Ji-Hong,CHEN Kun-Hua,ZHANG Ru-Yi et al. Combined Salbutamol and Ipratropium Bromide by inhalation in the Theatment of Child Asthma[J]. CJCP, 2000, 2(1): 12-14.
