Abstract：OBJECTIVE: To study the efficacy and safety of cellulose for the treatment of functional constipation in children. METHODS: A prospective, self-controlled, clinical trial using cellulose was conducted for 2 weeks in 34 children with functional constipation. The constipation symptoms and the characteristics of feces after the treatment were observed. RESULTS: The characteristics of feces and the constipation symptoms were improved significantly after the treatment. The total efficacy rate was 37% 3 days after treatment, 87% 7 days after treatment and 90% 14 days after treatment．The satisfactory rates of doctors and children′s parents on the therapeutic effects were 57% and 63%, respectively. No adverse events, such as abdominal distention, pain or diarrhea, were observed during the treatment. CONCLUSIONS: Cellulose is effective and safe in the treatment of functional constipation in children.
［1］Pare P, Ferrazzi S, Thompson WG, Irvine EJ, Rance L. An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking［J］. Am J Gastroenterol, 2001, 96(11):3130-3137.
［5］Riegler G, Esposito I. Bristol scale stool form. A still valid help in medical practice and clinical research［J］.Tech Coloproctol, 2001, 5(3): 163-164.
［8］Bleser SD.Chronic constipation: let symptom type and severity direct treatment［J］. J Fam Pract, 2006, 55(7): 587-593.
［9］Schiller LR. New and emerging treatment options for chronic constipation［J］.Rev Gastroenterol Disord, 2004, 4(Suppl 2): S43-S51.
［10］Camilleri M, Kerstens R, Rykx A, Vandeplassche L. A placebo-controlled trial of prucalopride for severe chronic constipation［J］.N Engl J Med, 2008, 358(22): 2344-2354.
［11］Wald A. Chronic constipation: advances in management［J］.Neurogastroenterol Motil, 2007, 19(1): 4-10.
