Abstract：OBJECTIVE: To study the risk factors for capillary leak syndrome (CLS) in neonates. METHODS: The clinical data of 52 neonates with CLS (case group) were retrospectively reviewed. Fifty hospitalized neonates without CLS were used as the control group. The possible factors for the development of CLS were identified by univariate analysis. The independent risk factors for CLS were determined by multivariate logistic regression analysis. RESULTS: The univariate analysis showed that the incidences of hyperglycemia, respiratory distress syndrome (RDS), sepsis and cold injury syndrome in the case group were significantly higher than those in the control group (P<0.05). The logistic regression analysis showed that sepsis (OR=5.004, P=0.001), RDS (OR=3.880, P=0.013) and cold injury syndrome (OR=3.207, P=0.023) were the independent risk factors for the development of CLS. CONCLUSIONS: RDS, sepsis and cold injury syndrome are independent risk factors for CLS in neonates. Hyperglycemia may be associated with the development of CLS.
［1］Marx G. Fluid therapy in sepsis with capillary leakage［J］. Eur J Anaesthesio1, 2003,20(6):429-442.
［2］Marx G, Vangerow B, Burczyk C, Gratz KF, Maassen N, Cobas Meyer M, et al. Evaluation of noninvasive determinants for capillary leakage syndrome in septic shock patients［J］. Intensive Care Med, 2000, 26(9): 1252-1258.
［3］Druey KM, Greipp PR. Narrative review: the systemic capillary leak syndrome［J］. Ann Intern Med, 2010, 153（2）: 90-98.
［5］Hamacher J, Lucas R, Lijnen HR, Buschke S, Dunant Y, Wendel A, et al. Tumor necrosis factoralpha and angiostatin are mediators of endothelial cytotoxicity in bronchoalveolar lavages of patients with acute respiratory distress syndrome［J］. Am J Respir Crit Care Med, 2002, 166(5): 651-656.
［6］Speziale G, Ferroni P, Ruvolo G, Fattouch K, Pulcinelli FM, Lenti L, et al. Effect of normothermic versus hypothermic cardiopulmonary bypass on cytokine production and platelet function［J］. J Cardiovasc Surg (Torino), 2000, 41(6):819-827.
