Abstract：OBJECTIVE: To compare the clinical efficacy of imported pulmonary surfactant (PS) pig lung phospholipids injection (pig PS) and domestic cattle lung surface-active agent (cattle PS) for the treatment of neonatal respiratory distress syndrome (NRDS). METHODS: A total of 180 cases of grade IV NRDS receiving pig PS (n=90) or cattle PS treatment (n=90) were enrolled. The blood gas analysis and chest X-ray results and the incidence of complications after treatment, and hospitalization time and cost were compared between the two treatment groups. RESULTS: The efficiency rate in the pig PS group (97%) was higher than in the catle PS group (83%) (P<0.01). The cure rate in the pig PS group was also higher than in the cattle PS group (84% vs 66%; P<0.01). The incidence of pneumothorax in the pig PS group was lower than in the cattle PS group (3% vs 7%; P<0.05). The hospitalization time in the pig PS group was shorter than in the cattle PS group (21±4 days vs 23±4 days; P<0.05). There were no significant differences in the total hospitalization cost between the two groups. CONCLUSIONS: Pig PS seems to be superior to cattle PS in the treatment of grade IV NRDS.
LIU Yun,LI Li,LIANG Wen-Ying et al. Comparisons of efficacy of different pulmonary surfactants for the treatment of neonatal respiratory distress syndrome[J]. CJCP, 2012, 14(4): 253-255.
［6］Ghaemi S, Mohamadymasodi M, Kelishadi R. Evaluation of the effects of surfactant replacement therapy in neonatal respiratory distress syndrome［J］. 中国当代儿科杂志, 2009, 11 (3): 188-190.
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