Analysis of hepatitis B surface antibody in 3022 children
LIN Xiao-Bi, WANG Xiao-Mei, LIU Pei-Ning, ZHANG Ying, WANG Yi-Wen, CHEN Ke, YE Yi, CHEN Yi-Li, ZHOU Yong-Hai
Department of Child Health Care, Yuying Children’s Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang 325000, China. linxiaobi002021@163.com
Abstract：OBJECTIVE: To investigate the positive rate of hepatitis B surface antibody (HBsAb) in children. METHODS: Blood samples from 3022 children who received a physical examination in outpatient departments from 2009 to 2011 were subjected to serological test using ELISA to measure the positive rate of HBsAb. RESULTS: The positive rate of HBsAb decreased with age (P0.05), however the positive rate of HBsAb in boys aged one year and over was lower than in girls of the same age (P<0.01). The positive rate of HBsAb in boys aged between 3 and 4 years was higher than in girls of the same age (P<0.01). The positive rate of HBsAb decreased with age in boys, and was lower in those aged two years and over than in those aged one year and over (P<0.01). The positive rate of HBsAb also decreased with age in girls, with significant differences between different age groups (P<0.01). CONCLUSIONS: The positive rate of HBsAb decreases with age in children, so younger children have a higher risk of infection with hepatitis B virus. Serological monitoring of hepatitis B needs to be enhanced.
［6］Jafarzadeh A, Shokri F. The antibody response to HBs antigen is regulated by coordinated Th1 and Th2 cytokine production in healthy neonates［J］. Clin Ex Immunol, 2003,131(3): 451-456.
