Abstract：Objective To investigate the impact of continuous blood purification (CBP) on T-cell subsets and prognosis in children with severe sepsis. Methods A total of 42 children with severe sepsis were randomly divided into a control group (n=22) and a CBP group (n=20). The patients in the control group received conventional treatment, while those in the CBP group underwent continuous veno-venous hemofiltration daily 12-24 hours for 3 days besides conventional treatment. Changes in clinical variables and in peripheral blood regulatory T cell subsets were assessed 3 and 7 days after treatment. Results The pediatric intensive care unit length of stay and duration of mechanical ventilation were significantly shortened and the 28-day mortality rate was significantly lower in the CPB treatment group as compared with the control group (P+, CD4+, CD8+ T cell populations and PCIS scores were significantly higher at 3 and 7 days after treatment than before treatment (P+, CD4+, CD8+ T cell populations, CD4+/CD8+ ratio and PCIS scores were significantly higher in the CBP group than in the control group (PConclusions The CBP treatment may counteract the suppression of immune function and thus improve prognosis in children with severe sepsis.
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