Abstract：Objective To investigate the significance of serum cholesterol and fibrinogen (Fib) in evaluating the risk of glomerulosclerosis in children with nephrotic syndrome. Methods Sixty-three children with primary nephrotic syndrome were divided into two groups according to their pathological types: minimal change glomerulopathy (MCG) (n=39) and focal segmental glomerulosclerosis (FSGS) groups (n=24). Serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C and Fib and 24-hour urinary protein excretion were retrospectively analyzed. Results Serum levels of TC, non-HDL-C, and LDL-C were significantly higher in the FSGS group than in the MCG group (PP>0.05). According to the results of logistic regression analysis, high levels of LDL-C, non-HDL-C and TC were risk factors for FSGS (PPP>0.05). Conclusions Serum cholesterol, especially non-LDL-C, is of great significance in evaluating the risk of glomerulosclerosis in children with nephrotic syndrome. There is no sufficient evidence to support serum Fib as a marker for predicting glomerulosclerosis in these children.
ZHANG Jian-Jiang,FU Shu-Qin,DOU Wen-Jie et al. Significance of serum cholesterol and fibrinogen in evaluating the risk of glomerulosc-lerosis in children with nephrotic syndrome[J]. CJCP, 2014, 16(4): 356-360.
D'Agati VD, Fogo AB, Bruijn JA, et a1. Pathological classification of focal segmental glomeruloscleresis: a working proposal[J]. Am J Kidney Dis, 2004, 43(2): 368-382.
Lee HS. Mechanisms and consequences of hypertriglyceridemia and cellular lipid accumulation in chronic kidney disease and metabolic syndrome[J]. Histol Histopathol, 2011, 26(12): 1599-1610.
Contois JH, Warnick GR, Sniderman AD. Reliability of low-density lipoproteincholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B measurement[J]. J Clin Lipidol, 2011, 5(4): 264-272.
[14]
Sniderman AD, Islam S, Yusuf S, et al. Discordance analysis of Apolipoprotein B and non-high density lipoprotein cholesterol as markers of cardiovascular risk in the INTERHEART study[J]. Atherosclerosis, 2012, 225(2): 444-449.
Abate N, Vega GL, Grundy SM. Variability in cholesterol content and physical properties of lipoproteins containing apolipoprotein B-100[J]. Atherosclerosis, 1993, 104(1-2): 159-171.
[18]
Okwuosa TM, Klein O, Chan C, et al. 13-year long-term associations between changes in traditional cardiovascular risk factors and changes in fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study[J]. Atherosclerosis, 2013, 226(1): 214-219.
