Abstract：Objective To study the effects of extensively hydrolyzed protein formula (eHF) on the feeding and growth in preterm infants through a multicenter controlled clinical study. Methods Preterm infants admitted to eight upper first-class hospitals in China between February 2012 and December 2013 were randomly selected. They were divided into two observation groups and two control groups. The first observation group consisted of preterm infants with a gestational age of Results A total of 328 preterm infants were enrolled. Preterm infants with a gestational age of PPPP>0.05). Preterm infants with a gestational age of 32-34 weeks in the observation group had significantly lower serum total bilirubin levels at 2 weeks after birth compared with the corresponding control group (PPP>0.05). Conclusions For preterm infants, eHF can improve gastrointestinal motility, accelerate bilirubin metabolism and excretion and does not increase the incidence of EUGR.
YU Mu-Xue,ZHUANG Si-Qi,WANG Dan-Hua et al. Effects of extensively hydrolyzed protein formula on feeding and growth in preterm infants：a multicenter controlled clinical study[J]. CJCP, 2014, 16(7): 684-690.
Clark RH, Thomas P, Peabody J. Extrauterine growth restriction remains a serious problem in prematurely born neonates[J]. Pediatrics, 2003, 111(5 Pt 1): 986-990.
[9]
Fenton TR, Kim JH. A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants[J]. BMC Pediatr, 2013, 13: 59.
[10]
de Pipaon MM, Montes BM, Sanjose B, et al. Acquisition of full enteral feeds may depend on stooling pattern in very premature infants[J]. J Perinat Med, 2012, 40(4): 427-431.
[11]
Mihatsch WA, Franz AR, Lindner W, et al. Meconium passage in extremely low birthweight infants and its relation to very early enteral nutrition[J]. Acta Paediatr, 2001, 90(4): 409-411.
[12]
Mihatsch WA, Hogel J, Pohlandt F. Hydrolysed protein accelerates the gastrointestinal transport of formula in preterm infants[J]. Acta Paediatr, 2001, 90(2): 196-198.
[13]
Mihatsch WA, Franz AR, Hogel J, et al. Hydrolyzed protein accelerates feeding advancement in very low birth weight infants[J]. Pediatrics, 2002, 110(6): 1199-1203.
[14]
Corvaglia L, Mariani E, Aceti A, et al. Extensively hydrolyzed protein formula reduces acid gastro-esophageal reflux in symptomatic preterm infants[J]. Early Hum Dev, 2013, 89(7): 453-455.
[15]
Mihatsch WA, Franz AR, Kuhnt B, et al. Hydrolysis of casein accelerates gastrointestinal transit via reduction of opioid receptor agonists released from casein in rats[J]. Biol Neonate, 2005, 87(3): 160-163.
[16]
Riezzo G, Indrio F, Montagna O, et al. Gastric electrical activity and gastric emptying in preterm newborns fed standard and hydrolysate formulas[J]. J Pediatr Gastroenterol Nutr, 2001, 33(3): 290-295.
[17]
Kliegman R. Nelson Textbook of Pediatrics[M]. Elsevier/Saunders, 2011.
Picaud JC, Rigo J, Normand S, et al. Nutritional efficacy of preterm formula with a partially hydrolyzed protein source: a randomized pilot study[J]. J Pediatr Gastroenterol Nutr, 2001, 32(5): 555-561.
[20]
Drozdowski LA, Clandinin T, Thomson AB. Ontogeny, growth and development of the small intestine: Understanding pediatric gastroenterology[J]. World J Gastroenterol, 2010, 16(7): 787-799.
[21]
Rigo J, Salle BL, Picaud JC, et al. Nutritional evaluation of protein hydrolysate formulas[J]. Eur J Clin Nutr, 1995, 49 (Suppl 1): S26-S38.
[22]
Maggio L, Zuppa AA, Sawatzki G, et al. Higher urinary excretion of essential amino acids in preterm infants fed protein hydrolysates[J]. Acta Paediatr, 2005, 94(1): 75-84.
[23]
Florendo KN, Bellflower B, van Zwol A, et al. Growth in preterm infants fed either a partially hydrolyzed whey or an intact casein/whey preterm infant formula[J]. J Perinatol, 2009, 29(2): 106-111.
Szajewska H, Albrecht P, Stoitiska B, et al. Extensive and partial protein hydrolysate preterm formulas: the effect on growth rate, protein metabolism indices, and plasma amino acid concentrations[J]. J Pediatr Gastroenterol Nutr, 2001, 32(3): 303-309.
