Abstract：Objective To evaluate the value of high mobility group box 1(HMGB1) in the diagnosis of pediatric acute appendicitis. Methods The children with acute abdomen who had a diagnosis of suspected acute appendicitis between January and July 2013 and 25 healthy children were enrolled in this study. Serum HMGB1 levels were measured using ELISA on admission. The patients were classified into 2 groups according to surgery confirmation or pathological results: appendicitis（n=28) and non-appendicitis（n=35). Results Serum HMGB1 levels and WBC in the appendicitis and non-appendicitis groups were significantly higher than in the healthy children group（PPConclusion HMGB1 may play a role in the diagnosis of pediatric acute appendicitis.
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