Abstract：Objective To study the clinical characteristics of whooping cough in neonates and the antimicrobial resistance of the bacterial isolates. Methods Clinical information of 7 neonates with whooping cough confirmed by bacterial culture was collected. The antimirobial resistance of the isolates was tested using E-test and disk diffusion methods. Results The children's mothers or other family members had cough for more than 10 days in 6 neonates, in which four neonates contacted with 3 or more family members with cough. All the neonates had rhinobyon and slight cough at the beginning of the disease. Five cases presented typical spasmodic cough after 4-7 days of the onset. Five cases displayed cyanosis, four cases occurred apnea, three cases suffered breath holding, and only two cases had fever. Nares flaring and three depression signs were found in the physical examination. No bacteriostatic ring around the erythromycin disks were found for five bacterial isolates. The minimal inhibitory concentration (MIC) for erythromycin, azithromycin, clarithromycin and clindamycin were all >256 mg/L against the five isolates. Conclusions Whooping cough should be considered for neonates with respiratory symptoms and a history of close contact with respiratory infection patients. Macrolide-resistant Bordetella pertussis is common in children with whooping cough.
LUO Jie,WANG Hui-Xin,YUAN Lin et al. Clinical characteristics of whooping cough in neonates and antimicrobial resistance of the pathogenic bacteria[J]. CJCP, 2014, 16(10): 975-978.
Wendelboe AM, Hudgens MG, Poole C, et al. Estimating therole of casual contact from the community in transmissionof Bordetella pertussis to young infants[J]. Emerg ThemesEpidemiol, 2007, 4: 15.
[4]
Gregory DS. Pertussis: a disease affecting all ages[J]. Am FamPhysician, 2006, 74(3): 420-426.
[5]
Montella S, De Stefano S, Sperlì F, et al. Increased risk ofchronic suppurative lung disease after measles or pertussis innon-vaccinated children[J]. Vaccine, 2007, 25(3): 402-403.
CDC. Updated recommendations or use of tetanus toxoids,reduced diphtheria toxiod and acellular pertussis vaccine(Tdap) in pregnant women and persons who have or anticipatehaving close contact with an infant aged<12 months-AdvisoryCommittee on Immunization Practices(ACIP), 2011[J]. MMWR,2011, 60(41): 1424-1426.
[8]
De Serres G, Boulianne N, Duval B. Field effectiveness oferythromycin prophylaxis to prevent pertussis within families[J].Pediatr Infect Dis J, 1995, 14(11): 969-975.
[9]
Zhang Q, Li M, Wang L, et al. High-resolution melting analysisfor the detection of two erythromycin-resistant Bordetellapertussis strains carried by healthy schoolchildren in China[J].Clin Microbiol Infect, 2013, 19(6): E260-E262.
[10]
Wang Z, Li Y, Hou T, et al. Appearance of macrolide-resistantBordetella pertussis strains in China[J]. Antimicrob AgentsChemother, 2013, 57(10): 5193-5194.
