Abstract：Objective To study the changes and significance of serum hydrogen sulfide (H2S) levels in childrenwith benign infantile convulsions associated with mild gastroenteritis (BICE). Methods Forty-two hospitalized childrendiagnosed with BICE were recruited to the observation group, and 46 children admitted due to acute gastroenteritis alonewere recruited to the control group. Serum H2S levels were measured by a spectrophotometer. Results The serumH2S level in the observation group was significantly lower than in the control group (28±12 μmol/L vs 45±10 μmol/L; P<0.01). The patients with a number of convulsions greater than or equal to two had significantly lower serum H2Slevels than those with a number less than two (P<0.05). The number of convulsions was negatively correlated withserum H2S level in BICE patients (r=-0.485, P=0.001). When a convulsion exceeded 5 minues in duration, the durationwas negatively correlated with serum H2S level (r=-0.736, P=0.004). Conclusions The reduction in endogenous H2S level might be one of the causes of convulsions in BICE patients. The degree of reduction in H2S level is associated withthe number of convulsions and the duration of convulsion (when it exceeds 5 minues). Further investigation is needed todetermine the clinical significance of these results.
Huang CC, Chang YC, Wang ST. Acute symptomatic seizure disorders in young children:a population study in southern Taiwan [J]. Epilepsia, 1998, 39(9):960-964.
[3]
Kang B, Kim DH, Hong YJ, et al. Comparison between febrile and afebrile seizures associated with mild rotavirus gastroenteritis[J]. Seizure, 2013, 22(7):560-564.
Stipanuk MH, Beck PW. Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat[J]. Biochem J, 1982, 206(2):257-277.
Han Y, Qin J, Chang X, et a1. Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats[J]. Neurosci Res, 2005, 53(2):216-219.
[10]
Hassan H, Pohle W, Rüthrich H, et al. Repeated long-term potentiation induces mossy fiber sprouting and changes the sensibility of hippocampal granule cells to subconvulsive doses of pentylenetetrazol[J]. Eur J Neurosci, 2000, 12(4):1509-1515.
Kawashima H, Inage Y, Ogihara M, et al. Serum and cerebrospinal fluid nitrite/nitrate levels in patients with rotavirus gastroenteritis induced convulsion[J]. Life Sci, 2004, 74(11):1397-1405.
[13]
Rejdak K, Eikelenboom MJ, Petzold A, et al. CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis[J]. Neurology, 2004, 63(8):1439-1445.
[14]
Kimura Y, Kimura H. Hydrogen sulfide protects neurons from oxidative stress[J]. FASEB J, 2004, 18:1165-1167.
[15]
Kimura Y, Dargusch R, Schubert D, et al. Hydrogen sulfide protects HT22 neuronal cells from oxidative stress[J]. Antioxid Redox Signal, 2006, 8(3-4):661-670.
[16]
Meng JL, Mei WY, Dong YF, et al. Heat shock protein 90 mediates cytoprotection by H2S against chemical hypoxiainduced injury in PC12 cells[J]. Clin Exp Pharmacol Physiol, 2011, 38(1):42-49.
[17]
Gong QH, Shi XR, Hong ZY, et a1. A new hope for neurodegeneration:possible role of hydrogen sulfide[J]. J Alzheimers Dis, 2011, 24(2):173-182.
Zhang M, Shah H, Wang T, et a1. Dynamic change of hydrogen sulfide after traumatic brain injury and its effect in mice[J]. Neurochem Res, 2013, 38(4):714-725.
