Abstract：Objective To compare the maternal and perinatal outcomes of twin pregnancies conceived by in vitro fertilization (IVF) with outcomes of spontaneous twin pregnancies. Methods A retrospective analysis was conducted between January 2010 and April 2014 to investigate the maternal age, gestation length, modes of delivery, pregnancy complications and neonatal physical development, birth defects and perinatal diseases in 106 IVF-assisted twin pregnancies (IVF group) and 256 spontaneous twin pregnancies (control group). Results The mothers in the IVF group were significantly older than those in the control group (32±4 years vs 28±4 years, P<0.05). The incidence rates of gestational hypertension and gestational diabetes in the IVF group were significantly higher than in the control group (P<0.05). No significant differences were observed for neonatal physical development, the incidence of birth defects, and the incidence and mortality of perinatal diseases (P>0.05). Conclusions Twins conceived by IVF have similar outcomes as spontaneously conceived twins in the perinatal period. However, special attention is needed to monitor the levels of blood pressure and blood glucose for pregnant women with twins conceived by IVF during prenatal checkups.
ZHANG Hui-Qin,FAN Rui,TIAN Guo-Hua et al. Clinical outcomes of twin pregnancies conceived by in vitro fertilization compared with spontaneous twin pregnancies[J]. CJCP, 2015, 17(1): 63-67.
Paoloni Giacobino A. Epigenetics in reproductive medicine[J]. Pediatr Res, 2007, 61(5 pt 2): 51R-57R.
[3]
Anja P, Anne L, Steen R, et al. Neonatal outcome in a Danish national cohort of 3438 IVF/IC SI and 10362 non-IVF/IC SI twins born between 1995 and 2000[J]. Hum Reprod, 2004, 19(2): 435.
[4]
McDonald S, Murphy K, Beyene J, et al. Outcomes of in vitro fertilization twins: a systematic review and meta-analyses[J]. Am J Obstet Gynecol, 2005, 193(1): 141-152.
[5]
Nassar AH, Usta IM, Rechdan JB, et al. Pregnancy outcome in spontaneous twins versus twins who were conceived through in vitro fertilization[J]. Am J Obstet Gynecol, 2003, 189(2): 513-518.
[6]
Adler-Levy Y, Lunenfeld E, Levy A. Obstetric outcome of twin pregnancies conceived by in vitro fertilization and ovulation induction compared with those conceived spontaneously[J]. Eur J Obstet Gynecol Reprod Biol, 2007, 133(2): 173-178.
Luke B, Brown MB, Nugent C, et al. Risk factors for adverse outcomes in spontaneous conception versus assisted conception twin pregnancies[J]. Fertil Steril, 2004, 81(2): 315-319.
Choi SJ, Kim HS, Roh CR. Pregnancy outcomes of twins after in vitro and spontaneous fertilization[J]. Int J Gynecol Obstet, 2006, 94(1): 49-51.
[15]
Vasario E, Borgarello V, Bossotti C, et al. IVF twins have similar obstetric and neonatal outcome as spontaneously conceived twins: a prospective follow-up study[J]. Reprod Biomed Online, 2010, 21(3): 422-428.
VanBeijsterveldt CEM, Bartels M, Boomsma DI. Comparison of naturally conceived and IVF-DZ twins in the Netherlands Twin Registry: a developmental study[J]. J Pregnancy, 2011, 2011: 517614.
McDonald SD, Han Z, Mulla S, et al. Preterm birth and low birth weight among in vitro fertilization twins: a systematic review and meta-analyses[J]. Eur J Obstet Gynecol Reprod Biol, 2010, 148(2): 105-113.
[20]
Lambalk C, van Hooff M. Natural versus induced twinning and pregnancy outcome: a Dutch nationwide survey of primiparous dizygotic twin deliveries[J]. Fertil Steril, 2001, 75(4): 731-736.
[21]
Olivennes F, Kadhel P, Rufat P, et al. Perinatal outcome of twin pregnancies obtained after in vitro fertilization: comparison with twin pregnancies obtained spontaneously or after ovarian stimulation[J]. Fertil Steril, 1996, 66(1): 105-109.
[22]
Daniel Y, Ochshorn Y, Fait G, et al. Analysis of 104 twin pregnancies conceived with assisted reproductive technologies and 193 spontaneuously conceived twin pregnancies[J]. Fertil Steril, 2000, 74(4): 653-659.
Wang XM, Chang YM, Zhao XY, et al. Study on the neonatal outcomes and congenital malformations in children born after in-vitro fertilization[J]. Chin J Perinat Med, 2005, 8(4): 246-250.
[25]
Koivurova S, Hartikainen AL, Gissler M, et al. Neonatal outcome and congenital malformations in children born after invitro fertilization[J]. Hum Reprod, 2002, 17(5): 1391.
[26]
Cooke RWI. Neonatal care of twins[M]//Ward RH, Whittle M. Multiple pregnancy. London: RCOG Press, 1995: 283-296.
[27]
Practice Committee of American Society for Reproductive Medicine; Practice Committee of Society for Assisted Reproductive Technology. Genetic considerations related to intracytoplasmic sperm injection(ICSI)[J]. Fertil Steril, 2008, 90(5 Suppl): S182-S184.
[28]
Kurinczuk JJ. Safety issues in assisted reproduction technology. From theory to reality-just what are the data telling us about ICSI of spring health and future fertility and should we be concerned[J]. Hum Reprod, 2003, 18(5): 925-931.
