Abstract：Objective To explore the factors influencing cognitive functions in patients with childhood and adolescence-onset schizophrenia. Methods The clinical data of 78 patients with childhood and adolescence-onset schizophrenia who met with the criteria of ICD-10 for schizophrenia were retrospectively reviewed. The cognitive functions were evaluated by the Chinese Wechsler Intelligence Scale for Children (C-WISC), the Wisconsin Card Sorting Test (WCST), digit span backward and P300. The clinical symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS). Results The patients with a lower education level or earlier onset of age had a longer P3 latency at the P300Fz area. The patients with a higher parental education level had higher scores of full intelligence quotient (FIQ), verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ), conceptual level and completed categories of WCST and backward numeric order reciting. The patients with higher PANSS negative subscale scores had lower scores of FIQ, VIQ, PIQ, completed categories and conceptual level of WCST and backward numeric order reciting. The patients with a longer stabilization time had higher backward numeric order reciting scores. Conclusions The severity of negative symptoms of the patients and the educational level of their parents are major factors influencing cognitive functions in patients with childhood and adolescence-onset schizophrenia.
CAO Yang,KANG Chuan-Yuan,WAN Shuai et al. Relationship between clinical features and cognitive function in patients with childhood and adolescence-onset schizophrenia[J]. CJCP, 2015, 17(4): 379-383.
Maccabe JH. Population-based cohort studies on premorbid cognitive function in schizophrenia[J]. Epidemiol Rev, 2008, 30(2): 77-83.
[2]
Reichenberg A, Weiser M, Rapp MA, et al. Premorbid intraindividual variability in intellectual performance and risk for schizophrenia: a population-based study[J]. Schizophr Res, 2006, 85(1-3): 49-57.
[3]
Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence [J]. Neuropsychology, 1998, 12 (3): 426-445.
[4]
Tsuang MT, Stone WS, Faraone SV. Schizophrenia: a review of genetic studies[J]. Harv Rev Psychiatry, 1999, 7(4): 185-207.
[5]
White T, HoBC, Ward J, et al. Neuropsychological performance in first-episode adolescents with schizophrenia: a comparison with first-episode adults and adolescent control subjects[J]. Biol Psychiatry, 2006, 60(5): 463-471.
Chun J, Karam ZN, Marzinzik F, et a1. Can P300 distinguish among schizophrenia, schizoaffective and bipolar I disorders? An ERP study of response inhibition[J]. Schizophr Res, 2013, 151(1-3): 175-184.
[11]
Goldberg X, Fatjó-Vilas M, Muñoz MJ, et al. Increased familiarity of intellectual deficits in early-onset schizophrenia spectrum disorders[J]. World J Biol Psychiatry, 2012, 13(7): 493-500.
[12]
Toulopoulou T, Goldberg TE, Mesa IR, et al. Impaired intellect and memory: a missing link between genetic risk and schizophrenia? [J]. Arch Gen Psychiatry, 2010, 67(9): 905-913.
[13]
Cullen K, Guimaraes A, Wozniak J, et al. Trajectories of social withdrawal and cognitive decline in the schizophrenia prodrome[J]. Clin Schizophr Relat Psychoses, 2011, 4(4): 229- 238.
Bralet MC, Navarre M, Eskenazi AM, et al. [Interest of a new instrument to assess cognition in schizophrenia: The Brief Assessment of Cognition in Schizophrenia (BACS)][J]. Encephale, 2008, 34(6): 557-562.
[16]
White T, Langen C, Schmidt M, et al. Comparative neuropsychiatry: White matter abnormalities in children and adolescents with schizophrenia, bipolar affective disorder, and obsessive-compulsive disorder[J]. Eur Psychiatry, 2015, 30(2): 205-213.
[17]
Seidman LJ, Giuliano AJ, Smith CW, et al. Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside adolescent high risk studies [J]. Schizophr Bull, 2006, 32(3): 507-524.
[18]
Guo X, Li J, Wang J, et al. Hippocampal and orbital inferior frontal gray matter volume abnormalities and cognitive deficit in treatment-naive, first-episode patients with schizophrenia[J]. Schizophr Res, 2014, 152(2-3): 339-343.
[19]
Ma X, Wang Q, Sham PC, et al. Neurocognitive deficits in firstepisode schizophrenic patients and their first-degree relatives.[J]. Am J Med Genet B Neuropsychiatr Genet, 2007, 144B(4): 407- 416.
[20]
Qiu YQ, Tang Y, Chan R, et al. P300 aberration in first-episode schizophrenia patients: a meta-analysis [J]. PLoS One, 2014, 9(6): e97794.
Chang WH, Chen KC, Yang YK, et al. Association between auditory P300, psychopathology, and memory function in drugnaïve schizophrenia[J]. Kaohsiung J Med Sci, 2014, 30(3): 133- 138.
[23]
Bellino S. Relationships of age at onset with clinical features and cognitive functions in a sample of schizophrenia patients [J]. Clin Psychiatry, 2004, 65(7): 908-914.
