Abstract：Objective To examine fractional exhaled nitric oxide (FeNO) values in 1-3-year-old children with asthma and analyze the correlation of FeNO with peripheral blood eosinophils (EOS) and lung function in these children. Methods A total of 111 children aged 1-3 years with asthma were enrolled. The children were classified into acute exacerbation (n=62) and remission groups (n=49) according to their symptoms. FeNO values, lung function, and peripheral blood EOS count were measured in these children. Sixty age-matched healthy children were enrolled as the control group. Results FeNO values were significantly higher in the acute exacerbation group (24.4 ppb) than in the remission group (18.0 ppb) and the control group (13.7 ppb) (P<0.05). The FeNO values in the remission group were significantly higher than in the control group (P<0.05). FeNO values were not significantly correlated with peripheral blood EOS count and lung function parameters (PEF, TEF25, TEF50, and TEF75) . Conclusions Measurement of FeNO is useful to evaluate the disease activity in children with asthma aged 1 to 3 years, but the FeNO values are not correlated with peripheral blood EOS count and lung function.
TIAN Wen-Qiu,AN Shu-Hua,LI Jin-Ying. Correlation of fractional exhaled nitric oxide with peripheral blood eosinophils and lung function in 1-3-year-old children with asthma[J]. CJCP, 2015, 17(4): 317-320.
Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics[J]. Eur Respir J, 1993, 6(9): 1368-1370.
[2]
Lex C, Ferreira F, Zacharasiewicz A, et al. Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests[J]. Am J Respir Crit Care Med, 2006, 174(12): 1286-1291.
[3]
Holz O, Mücke M, Zarza P, et al. Freezing of homogenized sputum samples for intermittent storage[J]. Clin Exp Allergy, 2001, 31(8): 1328-1331.
Dweik RA, Boggs PB, Erz urum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitirc oxide levels(FENO) for clinical applications[J]. Am J Respir Crict Care Med, 2011, 184(5): 602-615.
[11]
Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention[EB/OL]. Updated 2011, URL: Http://www.gina asthma.org.
[12]
Bjermer L, Alving K, Diamant Z, et al. Current evidence and future research needs for FeNO measurement in respiratory diseases[J]. Respir Med, 2014, 108(6): 830-841.
[13]
Hammermann R, Hirschmann J, Hey C, et al. Cationic proteins inhibit L-arginine uptake in rat alveolar macrophages and tracheal epithelial cells.Implications for nitric oxide synthesis[J]. Am J Respir Cell Mol Biol, 1999, 21(2): 155-162.
Covar RA, Szefler SJ, Martin RJ, et al. Relations between exhaled nitric oxide and measures of diseases activity among children with mild-to-moderate asthma[J]. J Pediatr, 2003, 142(5): 469-475.
[16]
American Thoracic Society; European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005[J]. Am J Respir Crit Care Med, 2005, 171(8): 912-930.
[17]
Horvath I, de Jongste JC. Exhaled nitric oxide in infants: a marker of inflammation[J]. Eur Respir Soc Mon, 2010, 49: 56- 70.
[18]
Cobos Barroso N, Pérez-Yarza EG, Sardón Prado O, et al. Exhaled nitric oxide in children: a noninvasive marker of airway inflammation[J]. Arch Bronconeumol, 2008, 44(1): 41-51.
[19]
Hylke H, Marianne L, Franka H, et al. Reference values of exhaled nitric oxide in healthy children 1-5 years using off-line tidal breathing[J]. Pediatr Pulmonol, 2014, 49(3): 291-295.
