Abstract：Objective To study the expression profile and significance of serum transforming growth factor-beta 1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) in preterm infants with respiratory distress syndrome (RDS). Methods Thirty-two preterm infants with RDS who were given pulmonary surfactant (PS) within 12 hours after birth were enrolled as the PS group. Twenty-eight preterm infants with RDS who were not given PS were selected as the non-PS group. Another 30 preterm infants without RDS were used as the control group. Serum levels of TGF-β1 and BMP-7 in the three groups were measured using enzyme-linked immunosorbent assay at 0, 1, 3, and 7 days after birth. Results The PS group had higher serum levels of TGF-β1 than the control group at 1 and 3 days after birth (PPPPPPConclusions Both serum TGF-β1 and BMP-7 levels increase in the early stage in preterm infants with RDS, however, in the late stage, the expresssion of BMP-7 decreases with the increase in TGF-β1 expression, suggesting that administration of exogenous BMP-7 may reduce the expression of TGF-β1, which might be a therapeutic approach for RDS in preterm infants.
LI Xiao-Qing,ZHENG Ling-Fang. Expression profile of TGF-β1 and BMP-7 in serum of preterm infants with respiratory distress syndrome[J]. CJCP, 2015, 17(5): 445-448.
Kamath BD, Macquire ER, McClure EM, et al. Neonatal mortality from respiratory distress syndrome: lessons for low-resource countries[J]. Pediatrics, 2011, 127(6): 1139-1146.
[2]
Ma L, Liu C, Wang Y, et al. Mortality of neonatal respiratory failure related to socioeconomic factors in Hebei province of China[J]. Neonatology, 2011, 100(1): 14-22.
[3]
Ruegger C, Hegglin M, Adams M, et al. Swiss Neonatal Network. Population based trends in mortality, morbidity and treatment for very preterm-and very low birth weight infants over 12 years[J]. BMC Pediatr, 2012, 12: 17.
Sezer RG, Aydemir G, Bozaykut A, et al. The relationship between the first episode of wheezing and matrix metalloproteinases-9 and MMP-2 and tissue inhibitors of MMP-1 levels in preterm infants[J]. Ann Thorac Med, 2013, 4(8): 209-213.
[6]
Patel AS, Song JW, Chu SG, et al. Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis[J]. PLoS One, 2015, 10(3): e0121246.
Stumm CL, Halcsik E, Landgraf RG, et al. Lung remodeling in a mouse model of asthma involves a balance between TGF-β1 and BMP-7[J]. PLoS One, 2014, 9(4): e95959.
Sharon LP. Prolonged mechanical ventilation in children[J]. Pediatr Clin North Am, 1994, 41(3): 473-512.
[11]
Britt RD Jr, Velten M, Tipple TE, et al. Cyclooxygenase-2 in newborn hyperoxic lung injury [J]. Free Radic Biol Med, 2013, 61C(8): 502-511.
[12]
Gaede KI, Amicosante M, Schurmann M, et al. Function associated transforming growth factor-beta gene polymorphism in chronic beryllium disease[J]. J Mol Med, 2005, 83(5): 397-405.
