Abstract：Objective To investigate adipokines levels in obese children with acanthosis nigricans (AN) and to explore the relationship between AN and metabolic syndrome (MS). Methods A cross-sectional study was performed on 109 obese children and 47 age-and gender-matched normal controls. The obese children were divided into two groups with AN and without AN. Serum levels of adiponectin, leptin, TNF-α and retinol-binding protein 4 (RBP4) were measured using ELISA. Multiple logistic regression analysis was performed to estimate the association of clinical parameters with MS. Results Waist-hip ratio, systolic blood pressure, triglyceride, fasting insulin and insulin resistance index (HOMA-IR) were significantly higher in obese children with AN than in those without AN and normal controls (P<0.05). The obese children with AN and without AN had lower adiponectin levels than normal controls (P<0.05), on the contrary, the obese children with AN had higher leptin levels than those without AN and normal controls (P<0.05). Multiple logistic regression analysis revealed that AN (OR=3.469, 95%CI: 1.518-7.929) and BMI (OR=7.108, 95%CI: 2.359-21.416) were independent risk factors for MS. Conclusions As a visible marker of insulin resistance, AN is associated with abnormal adipokines secretion. Reducing the incidence of AN and losing weight may prevent obesity associated MS.
TAN Xin-Rui,ZHANG Mei-Zhen,LI Min et al. Association between acanthosis nigricans and metabolic syndrome in children with obesity[J]. CJCP, 2015, 17(7): 672-676.
Buzasi K, Sapi Z, Jermendy G. Acanthosis nigricans as a local cutaneous side effect of repeated human insulin injections[J]. Diabetes Res Clin Pr, 2011, 94(2): E34-E36.
[1]
Simonneau G, Gatzoulis MA, Adatial I, et al. Updated clinical classification of pulmonary hypertension[J]. J Am Coll Cardiol, 2013, 62(25 Suppl): D34-D41.
[26]
Ghosh S, Roychowdhury B, Mukhopadhyay S, et al. Clearance of acanthosis nigricans associated with insulinoma following surgical resection[J]. QJM-AN Int J Med, 2008, 101(11): 899-900.
[2]
Li J, Kim SG, Blenis J. Rapamycin: One drug, many effects[J]. Cell Metabolism, 2014, 19(3): 373-379.
[27]
Goren I, Pfeilschifter J, Frank S. Determination of leptin signaling pathways in human and murine keratinocytes[J]. Biochem Bioph Res Co, 2003, 303(4): 1080-1085.
[3]
Rao RD, Buckner JC, Sarkaria JN. Mammalian target of rapamycin (mTOR) inhibitors as anti-cancer agents[J]. Curr Cancer Drug Targets, 2004, 4(8): 621-635.
[28]
Atwa M, Emara A, Balata M, et al. Serum leptin, adiponectin, and resistin among adult patients with acanthosis nigricans: correlations with insulin resistance and risk factors for cardiovascular disease[J]. Int J Dermatol, 2014, 53(10): e410-e420.
