Abstract：Objective To explore the effects of body mass index (BMI) and the levels of serum inflammatory cytokines on asthma control in children with asthma. Methods One hundred and sixteen children with asthma were divided into three groups: normal (n=59), thin (n=31), and obesity (n=26) based on their BMI. The levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were determined using ELISA, and the level of high-sensitivity C-reactive protein (hs-CRP) was measured by immunoturbidimetric assays. Asthma control status in each group was evaluated by the Childhood Asthma Control Test (C-ACT) after 4 weeks of treatment. Results The serum levels of IL-6, hs-CRP, and TNF-α were highest in the obesity group, followed by the thin group and the normal group (PPPP>0.05). The levels of IL-6, hs-CRP, and TNF-α were negatively correlated with the C-ACT score (PP>0.05). Conclusions When BMI is too high or too low, the levels of serum inflammatory cytokines are all increased, which is harmful to asthma control. Maintaining a healthy weight in children with asthma may reduce the levels of serum inflammatory cytokines and improve the asthma control rate.
CHEN Xiao-Jian,ZHANG Yue-Hua,WANG Dan-Hong et al. Effects of body mass index and serum inflammatory cytokines on asthma control in children with asthma[J]. CJCP, 2015, 17(7): 698-701.
Ziora D, Sitek P, Machura E, et al. Bronchial asthma in obesity-a distinct phenotype of asthma?[J]. Pneumonol Alergol Pol, 2012, 80(5): 454-462.
[3]
Hjellvik V, Tverdal A, Furu K. Body mass index as predictor for asthma: a cohort study of 118,723 males and females[J]. Eur Respir J, 2010, 35(6): 1235-1242.
[4]
Mosen DM, Schatz M, Magid DJ, et al. The relationship between obesity and asthma severity and control in adults[J]. J Allergy Clin Immunol, 2008, 122(3): 507-511.
[5]
Krystofova J, Jesenak M, Banovcin P. Bronchial asthma and obesity in childhood[J]. Acta Medica(Hradec Kralove), 2011, 54(3): 102-106.
[6]
Roth CL, Kratz M, Ralston MM, et al. Changes in adiposederived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children[J]. Metabolism, 2011, 60(4): 445-452.
Elshorbagy AK, Valdivia-Garcia M, Refsum H, et al. The association of cysteine with obesity, inflammatory cytokines and insulin resistance in Hispanic children and adolescents[J]. PloS One, 2012, 7(9): e44166.
Liu AH, Zeiger R, Sorkness C, et al. Development and crosssectional validation of the Childhood Asthma Control Test[J]. J Allergy Clin Immunol, 2007, 119(4): 817.
Gong L, Yuan F, Teng J, et al. Weight loss, inflammatory markers, and improvements of iron status in overweight and obese children[J]. J Pediatr, 2014, 164(4): 795-800.
[17]
Cao J, Chen JH, Zhu SY. Effects of leptin on airway inflammation and the expression of Th1/Th2 cytokines in asthmatic rats[J]. Zhonghua Jie He He Hu Xi Za Zhi, 2009, 32(3):171-176.
[18]
Chalise SP, Bhatta NK, Singh RR, et al. Assessment of control of bronchial asthma in children using Childhood Asthma Control Test[J]. Indian J Chest Dis Allied Sci, 2014, 56(2): 75-78.
[19]
Liu AH, Zeiger R, Sorkness C, et al. Development and cross -sectional validation of the Childhood Asthma Control Test[J]. J Allergy Clin Immunol, 2007, 119(4): 817.
[20]
Jensen ME, Wood LG, Gibson PG. Obesity and childhood asthma-mechanisms and manifestations[J]. Curr Opin Allergy Clin Immunol, 2012, 12(2): 186-192.
