Effects of obesity on peak level of luteinizing hormone in gonadotropin-releasing hormone agonist test and obesity-related hormones in girls with central precocious puberty
ZHOU Xue-Lian1, FU Jun-Fen1, JIN Ju-Hua2, DONG Guan-Ping1, JIANG You-Jun1, HUANG Ke1, CHEN Xue-Feng1, WU Wei1
Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China
Abstract：Objective To explore the effects of obesity on the peak level of luteinizing hormone (LH) in the gonadotropin-releasing hormone (GnRH) agonist test and obesity-related hormones in girls with central precocious puberty (CPP). Methods Three hundred and thirty-three girls with CPP who underwent the GnRH agonist test between 2012 and 2014 were classified into three groups: normal weight (n=123), overweight (n=108), and obesity (n=102), according to body mass index (BMI). The sexual development indices were compared between the three groups. Twenty girls were randomly selected from each group for evaluation of the serum levels of leptin, sex hormone binding globulin (SHBG), neurokinin B, and kisspeptin. The correlation of BMI with the levels of various hormones was assessed using Pearson correlation analysis. Results There was no significant difference in mean age at diagnosis between the three groups; however, the bone age was significantly higher in the overweight and obesity groups than in the normal weight group (P< 0.05). The peak level of LH in the GnRH agonist test and SHBG level in the normal weight group were significantly higher than those in the overweight and the obesity groups, while the serum levels of leptin and neurokinin B were significantly lower in the normal weight group than in the overweight and the obesity groups (P< 0.05). BMI was negatively correlated with the peak level of LH in the GnRH agonist test and SHBG level (P< 0.05), and positively correlated with the levels of leptin and neurokinin B (P< 0.05). Conclusions The effects of BMI on the result of the GnRH agonist test and levels of obesity-related hormones should be taken into account in girls with precocious puberty.
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