Abstract：Objective To study whether infantile wheezing pneumonia has similar immune mechanisms to asthma by determining the levels of serum inflammatory factors in wheezing infants with community-acquired pneumonia (CAP). Methods Forty-two infants with CAP but without wheezing, 47 infants with CAP and wheezing, and 30 healthy infants as a control were recruited in the study. The peripheral blood levels of C-reactive protein, procalcitonin, soluble triggering receptor expressed on myeloid cell-l, interferon-γ, interleukin-4, interleukin-10, and periostin were compared in the three groups. Results The serum levels of procalcitonin, soluble triggering receptor expressed on myeloid cell-l, interleukin-4 and interleukin-10 in the two CAP groups were higher than in the control group (PPPConclusions The unbalanced ratio of interferon-γ/interleukin-4 and airway eosinophilic inflammation in wheezing infants with pneumonia suggest infantile pneumonia with wheezing may has similar immune mechanisms to asthma.
Hoshino M, Ohtawa J, Akitsu K. Increased C-reactive protein is associated with airway wall thickness in steroid-naive asthma[J]. Ann Allergy Asthma Immunol, 2014, 113(1): 37-41.
[3]
Phua J, Koay ES, Zhang D, et al. Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections[J]. Eur Respir J, 2006, 28(4): 695-702.
[4]
Darveaux JI, Lemanske RF Jr. Infection-related asthma[J]. J Allergy Clin Immunol Pract, 2014, 2(6): 658-663.
[5]
Gibot S, Cravoisy A, Levy B, et al. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia[J]. N Engl J Med, 2004, 350(5): 451-458.
[6]
Oku R, Oda S, Nakada TA, et al. Differential pattern of cell-surface and soluble TREM-1 between sepsis and SIRS[J]. Cytokine, 2013, 61(1): 112-117.
[7]
Kalliola S, Pelkonen AS, Malmberg LP, et al. Maternal smoking affects lung function and airway inflammation in young children with multiple-trigger wheeze[J]. J Allergy Clin Immunol, 2013, 131(3): 730-735.
[8]
Kusel MM, Kebadze T, Johnston SL, et al. Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze[J]. Eur Respir J, 2012, 39(4): 876-882.
