Abstract：Objective To examine serum 25-hydroxyvitamin D levels in children with attention deficit hyperactivity disorder (ADHD) and to explore the relationship between vitamin D level and ADHD. Methods Ninety-seven children with ADHD who were diagnosed according to DSM-V were selected as the ADHD group, including 46 cases of ADHD-I, 10 cases of ADHD-HI, and 41 cases of ADHD-C. Ninety-seven healthy children served as the control group. Serum levels of 25-hydroxyvitamin D were measured using electrochemiluminescence immunoassay. Results Mean serum levels of 25-hydroxyvitamin D in the ADHD group (17±7 ng/mL) were significantly lower than in the control group (23±8 ng/mL; P< 0.01). The serum levels of 25-hydroxyvitamin D in the three subtypes groups of ADHD (ADHD-I, ADHD-HI, and ADHD-C) were all lower than in the control group (P< 0.05). The rates of vitamin D insufficiency, deficiency or normal in the ADHD group were different from the control group (P< 0.01). The distributions of vitamin D levels in the three subtypes groups of ADHD were all different from the control group (P< 0.05). Conclusions Serum levels of 25-hydroxyvitamin D in children with ADHD are lower than in healthy children, suggesting vitamin D level might be related to ADHD.
SHANG-GUAN Li-Li,ZHAO Ya-Ru. Serum levels of 25-hydroxyvitamin D in children with attention deficit hyperactivity disorder[J]. CJCP, 2015, 17(8): 837-840.
Goksugur SB, Tufan AE, Semiz M, et al. Vitamin D status in children with attention-deficit-hyperactivity disorder[J]. Pediatr Int, 2014, 56(4): 515-519.
[4]
Kamal M, Bener A, Ehlayel MS. Is high prevalence of vitamin D deficiency a correlate for attention deficit hyperactivity disorder?[J]. Atten Defic Hyperact Disord, 2014, 6(2): 73-78.
[5]
Cass WA, Smith MP, Peters LE. Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine[J]. Ann N Y Acad Sci, 2006, 1074(1): 261-271.
[6]
Harms LR, Eyles DW, McGrath JJ, et al. Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice[J]. Behav Brain Res, 2008, 187(2): 343-350.
[7]
Gallo S, Jean-Philippe S, Rodd C, et al. Vitamin D supplementation of Canadian infants: practices of Montreal mothers[J]. Appl Physiol Nutr Metab, 2010, 35(3): 303-309.
[8]
Eyles DW, Smith S, Kinobe R, et al. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain[J]. J Chem Neuroanat, 2005, 29(1): 21-30.
Bulut M, Selek S, Gergerlioglu HS, et al. Malondialdehyde levels in adult attention-deficit hyperactivity disorder[J]. J Psychiatry Neurosci, 2007, 32(6): 435-438.
[12]
Gordon CM, Feldman HA, Sinclair L, et al. Prevalence of vitamin D deficiency among healthy infants and toddlers[J]. Arch Pediatr AdolescMed, 2008, 162(6): 505-512.
