Abstract：Objective To determine the expression of high-mobility group protein box 1 (HMGB1), high-sensitivity C-reactive protein (hs-CRP), and D-dimer (D-D) in the peripheral blood of children with Henoch-Schönlein purpura (HSP) and to investigate the clinical significance of HMGB1 in children with HSP. Methods A total of 40 children with HSP (HSP group) and 30 healthy children (control group) were involved in the study. The level of serum HMGB1 was determined using enzyme-linked immunosorbent assay, and the levels of serum hs-CRP and plasma D-D were determined using automatic biochemical analyzer and automatic blood coagulation analyzer, respectively. Results The levels of HMGB1, hs-CRP, and D-D in the peripheral blood of the HSP group in the acute phase were significantly higher than in the control group (PPr=0.878, Pr=0.625, PConclusions The expression of HMGB1 is related to the inflammatory response and hypercoagulability in children with HSP. HMGB1 may be involved in the development of HSP and associated renal damage in children.
WANG Feng-Ying,JIANG Xing-Mei,LU Man. Expression and clinical significance of serum high-mobility group protein box 1 in children with Henoch-Schönlein purpura[J]. CJCP, 2015, 17(8): 792-795.
Rigante D, Castellazzi L, Bosco A, et al. Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura?[J]. Autoimmun Rev, 2013, 12(10): 1016-1021.
Huang W, Tang Y, Li LH. MGB1, a potent proinflammatory cytokine in sepsis[J]. Cytokine, 2010, 51(2): 119-126.
[8]
Yang H, Tracey KJ. Targeting HMGB1 in inflammation[J]. Biochim Biophys Acta, 2010, 1799(1-2): 149-156.
[9]
Venereau E, Schiraldi M, Uguccioni M, et al. HMGB1 and leukocyte migration during trauma and sterile inflammation[J]. Mol Immunol, 2013, 55(1): 76-82.
[10]
Wang H, Vishnubhakat JM, Bloom O, et al. Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes[J]. Surgery, 1999, 126(2): 389-392.
[11]
Beyer C, Stearns NA, Giessl A, et al. The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death[J]. Innate Immun, 2012, 18(5): 727-737.
[12]
Luo Y, Chihara Y, Fujimoto K, et al. High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy[J]. Eur J Cancer, 2013, 49(3): 741-751.
Kang R, Chen R, Zhang Q, et al. HMGB1 in health and disease[J]. Mol Aspects Med, 2014, 40C: 1-116.
[15]
Tanaskovic S, Isenovic ER, Radak D. Inflammation as a marker for the prediction of internal carotid artery restenosis following eversion endarterectomy-evidence from clinical studies[J]. Angiology, 2011, 62(7): 535-542.
Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis[J]. Psychosom Med, 2009, 71(2): 171-186.
Yilmaz D, Kavakli K, Ozkayin N. The elevated markers of hypercoagulability in children with Henoch-Schönlein purpura[J]. Pediatr Hematol Oncol, 2005, 22(1): 41-48.
Strizhakov LA, Chegaeva EP, Krivosheev OG, et al. Signs of hypercoagulation and activation of fibrinolysis in patients with Wegeners's granulomatosis and Schoenlein-Genoch's purpura[J]. Klin Med (Mosk), 2012, 90(5): 43-45.
Nogueira-Machado JA, de Oliveira Volpe CM. HMGB-1 as a target for inflammation controlling[J]. Recent Pat Endocr Metab Immune Drug Discov, 2012, 6(3): 201-209.
