血液灌流治疗对过敏性紫癜患儿血清IL-23及IL-17水平的影响及意义

刘丽; 黄燕萍; 房夏玲; 张渊源; 陈宁; 侯红红

doi:10.7499/j.issn.1008-8830.2015.08.007

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中国当代儿科杂志 ›› 2015, Vol. 17 ›› Issue (8) : 796-799. DOI: 10.7499/j.issn.1008-8830.2015.08.007

论著·临床研究

血液灌流治疗对过敏性紫癜患儿血清IL-23及IL-17水平的影响及意义

刘丽, 黄燕萍, 房夏玲, 张渊源, 陈宁, 侯红红

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Effects of hemoperfusion treatment on serum IL-23 and IL-17 levels in children with Henoch-Schönlein purpure

LIU Li, HUANG Yan-Ping, FANG Xia-Ling, ZHANG Yuan-Yuan, CHEN Ning, HOU Hong-Hong

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摘要

目的探讨血液灌流治疗对过敏性紫癜(HSP)患儿血清白介素(IL)17和IL-23水平的影响及临床意义。方法选取2011年1月至2012年12月诊断为HSP的患儿87例为病例组,所有患儿均行血液灌流治疗;另选取27例健康儿童为对照组。采用ELISA法检测HSP患儿治疗前后及对照组血清IL-17和IL-23的水平。结果 HSP患儿治疗前血清IL-23及IL-17水平均明显高于对照组(P< 0.05);HSP患儿治疗后血清IL-23及IL-17水平较治疗前均显著降低(P< 0.05),与对照组比较差异无统计学意义(P> 0.05)。HSP患儿血清IL-23与IL-17表达水平呈正相关(P< 0.05)。结论 IL-23和IL-17可能同时参与了HSP的发病过程。血液灌流治疗可以有效降低HSP患儿血清IL-23、IL-17水平,是有效的治疗HSP的方法之一。

Abstract

Objective To study the effects of hemoperfusion treatment on serum interleukin-17 (IL-17) and IL-23 levels in children with Henoch-Schönlein purpura (HSP). Methods Eighty-seven children who were diagnosed with HSP and who had received hemoperfusion treatment between January 2011 and December 2012 were enrolled. Twenty-seven sex- and age-matched healthy children were recruited as normal controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum concentrations of IL-17 and IL-23. Results The serum IL-23 and IL-17 levels in the HSP group were significantly higher than in the control group (P< 0.05). After hemoperfusion treatment, the serum IL-23 and IL-17 levels in the HSP group were significantly reduced to the levels of the control group. Serum serum IL-17 level was positively correlated with serum IL-23 level (P< 0.05) in children with HSP. Conclusions Hemoperfusion treatment can reduce serum IL-23 and IL-17 levels in children with HSP, suggesting that the treatment may be effective for HSP.

导出引用

刘丽, 黄燕萍, 房夏玲, 张渊源, 陈宁, 侯红红. 血液灌流治疗对过敏性紫癜患儿血清IL-23及IL-17水平的影响及意义[J]. 中国当代儿科杂志. 2015, 17(8): 796-799 https://doi.org/10.7499/j.issn.1008-8830.2015.08.007

LIU Li, HUANG Yan-Ping, FANG Xia-Ling, ZHANG Yuan-Yuan, CHEN Ning, HOU Hong-Hong. Effects of hemoperfusion treatment on serum IL-23 and IL-17 levels in children with Henoch-Schönlein purpure[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(8): 796-799 https://doi.org/10.7499/j.issn.1008-8830.2015.08.007

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