Abstract:Objective To study the effects of postnatal growth retardation on early neurodevelopment in premature infants with intrauterine growth retardation (IUGR).Methods A retrospective analysis was performed on the clinical data of 171 premature infants who were born between May 2008 and May 2012 and were followed up until a corrected gestational age of 6 months. These infants were classified into two groups:IUGR group (n=40) and appropriate for gestational age (AGA) group (n=131). The growth retardation rates at the corrected gestational ages of 40 weeks, 3 months, and 6 months, as well as the neurodevelopmental outcome (evaluated by Gesell Developmental Scale) at corrected gestational ages of 3 and 6 months, were compared between the two groups.Results The growth retardation rate in the IUGR group was significantly higher than in the AGA group at the corrected gestational ages of 40 weeks, 3 months, and 6 months. All five developmental quotients evaluated by Gesell Developmental Scale (gross motor, fine motor, language, adaptability and individuality) in the IUGR group were significantly lower than in the AGA group at the corrected gestational ages of 3 months. At the corrected gestational age of 6 months, the developmental quotients of fine motor and language in the IUGR group were significantly lower than in the AGA group, however, there were no significant differences in the developmental quotients of gross motor, adaptability and individuality between the two groups. All five developmental quotients in IUGR infants with catch-up lag in weight were significantly lower than in IUGR and AGA infants who had caught up well.Conclusions Growth retardation at early postnatal stages may adversely affect the early neurodevelopment in infants with IUGR.
CAI Yue-Ju,SONG Yan-Yan,HUANG Zhi-Jian et al. Effects of postnatal growth retardation on early neurodevelopment in premature infants with intrauterine growth retardation[J]. CJCP, 2015, 17(9): 893-897.
Rogne T, Engstrom AA, Jacobsen GW, et al. Fetal growth, cognitive function, and brain volumes in childhood and adolescence[J]. Obstet Gynecol, 2015, 125(3):673-682.
[3]
Smithers LG, Lynch JW, Yang S, et al. Impact of neonatal growth on IQ and behavior at early school age[J]. Pediatrics, 2013, 132(1):e53-e60.
[4]
Belfort MB, Rifas-Shiman SL, Sullivan T, et al. Infant growth before and after term:effects on neurodevelopment in preterm infants[J]. Pediatrics, 2011, 128(4):e899-906.
[5]
Franz AR, Pohlandt F, Bode H, et al. Intrauterine, early neonatal, and postdischarge growth and neurodevelopmental outcome at 5.4 years in extremely preterm infants after intensive neonatal nutritional support[J]. Pediatrics, 2009, 123(1):e101-e109.
Tudehope D, Vento M, Bhutta Z, et al. Nutritional requirements and feeding recommendations for small for gestational age infants[J]. J Pediatr, 2013, 162(3):S81-S89.
[9]
Rogers EE, Piecuch RE. Neurodevelopmental outcomes of infants who experience intrauterine growth restriction[J]. Neo Reviews, 2009, 10(2):100-112.
[10]
Smic Klaric A, Kolundzic Z, Galic S, et al. Language development in preschool children born after asymmetrical intrauterine growth retardation[J]. Eur J Paediatr Neurol, 2012, 16(2):132-137.
[11]
Heinonen K, Raikkonen K, Pesonen AK, et a1. Behavioural symptoms of attention deficit/hyperactivity disorder in preterm and term children born small and appropriate for gestational age:a longitudinal study[J]. BMC Pediatr, 2010,10(15):91-94.
[12]
Agostoni C, Buonocore G, Carnielli VP. ESPGHAN Committee on Nutrition, Nutrient Supply for Preterm Infants:Commentary From the European Society for Pediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition[J]. J Pediatr Gastroenterol Nutr, 2010, 50(1):1-9.