Abstract：Objective To explore the risk factors for coronary artery lesions (CAL) secondary to Kawasaki disease (KD) in children.Methods The medical data of 895 children with KD were retrospectively reviewed. The patients were classified into two groups according to the presence of CAL:CAL (n=284) and control (n=611). The clinical and laboratory indices were compared between the two groups.The risk factors for the development of CAL in children with KD were identified by multiple logistic regression analysis.Results Male gender (OR=1.712), occurrence of non-CAL complications (OR=2.028), atypical KD (OR=3.655), intravenous immunoglobulin (IVIG) resistance (OR=2.912), more than 5 days of fever duration before IVIG treatment (OR=1.350), and increased serum procalcitonin (PCT) level (OR=1.068) were the independent risk factors for the development of CAL in children with KD (POR=0.931, PConclusions Male gender, atypical KD, occurrence of other non-CAL complications, long duration of fever and IVIG resistance are associated with an increased risk for CAL in children with KD. Serum PCT and ALB have little value in the prediction of CAL in children with KD.
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