Abstract：Objective To observe the changes in Th17 cell levels in bronchoalveolar lavage fluid in children of sepsis with acute lung injury and the relationship between the Th17 cell levels and prognosis.Methods Fifty children of sepsis with acute lung injury were enrolled in the study. The percentages of Th17 cells in bronchoalveolar lavage fluid were measured by flow cytometry. The patients of sepsis with acute lung injury were classified into three groups based on the Pediatric Critical Illness Score (PCIS):extremely critical, critical and non-critical. According to the clinical prognosis, the patients were classified into survical and death groups. Th17 cell levels were compared between the two groups. The relationship between Th17 cell levels and the PCIS scores was analyzed.Results With the increase in the severity of sepsis, Th17 cell levels in bronchoalveolar lavage fluid were gradually increased (Pr=-0.853; PPConclusions The increased Th17 cell levels in children of sepsis with acute lung injury are closely related to the severity and prognosis of patients, suggesting that Th17 cell levels can be used as a predictor of the severity and prognosis.
XIONG Yi,WANG Jian,WEI Di et al. Prognostic values of Th17 cells level in bronchoalveolar lavage fluid in children of sepsis with acute lung injury[J]. CJCP, 2015, 17(9): 942-945.
Ganjalikhani Hakemi M, Ghaedi K, Homayouni V, et al. Positive and negative regulation of Th17 cell differentiation:evaluating the impact of RORC2[J]. Cell J, 2014, 16(3):343-352.
Irvin C, Zafar I, Good J, et al. Increased frequency of dualpositive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma[J]. J Allergy Clin Immunol, 2014, 134(5):1175-1186.
[5]
马丽, 霍建民. Th17+ T 细胞吸烟与慢性阻塞性肺疾病的相 关性研究进展[J]. 中华临床医师杂志(电子版), 2013, 7(12):5561-5563.
[6]
Brunialti MK, Santos MC, Rigato O, et al. Increased percentages of T helper cells producing IL-17 and monocytes expressing markers of alternative activation in patients with sepsis[J]. PLoS One, 2012, 7(5):e37393.
[7]
Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign:international guidelines for management of severe sepsis and septic shock:2012[J]. Crit Care Med, 2013, 41(2):580-637.
Adamzik M, Broll J, Steinmann J, et al. An increased alveolar CD4+ CD25+ Foxp3+ T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality[J]. Intensive Care Med, 2013, 39(10):1743-1751.
Lubberts E. Role of T lymphocytes in the development of rheumatoid arthritis. implications for treatment[J]. Curr Pharm Des, 2014, 21(2):142-146.
[14]
Akinosoglou K, Alexopoulos D. Use of antiplatelet agents in sepsis:a glimpse into the future[J]. Thromb Res, 2014, 133(2):131-138.
[15]
Lin CW, Lo S, Hsu C, et al. T-cell autophagy deficiency increases mortality and suppresses immune responses after sepsis[J]. PLoS One, 2014, 9(7):e102066.[1] 刑柏, 曾琦, 谭世峰, 等. 呼吸指数对严重脓毒症患者预后 的评估价值[J]. 中国全科医学, 2013, 16(7B):2398-2400.
[2]
Ganjalikhani Hakemi M, Ghaedi K, Homayouni V, et al. Positive and negative regulation of Th17 cell differentiation:evaluating the impact of RORC2[J]. Cell J, 2014, 16(3):343-352.
Irvin C, Zafar I, Good J, et al. Increased frequency of dualpositive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma[J]. J Allergy Clin Immunol, 2014, 134(5):1175-1186.
[5]
马丽, 霍建民. Th17+ T 细胞吸烟与慢性阻塞性肺疾病的相 关性研究进展[J]. 中华临床医师杂志(电子版), 2013, 7(12):5561-5563.
[6]
Brunialti MK, Santos MC, Rigato O, et al. Increased percentages of T helper cells producing IL-17 and monocytes expressing markers of alternative activation in patients with sepsis[J]. PLoS One, 2012, 7(5):e37393.
[7]
Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign:international guidelines for management of severe sepsis and septic shock:2012[J]. Crit Care Med, 2013, 41(2):580-637.
Adamzik M, Broll J, Steinmann J, et al. An increased alveolar CD4+ CD25+ Foxp3+ T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality[J]. Intensive Care Med, 2013, 39(10):1743-1751.
Lubberts E. Role of T lymphocytes in the development of rheumatoid arthritis. implications for treatment[J]. Curr Pharm Des, 2014, 21(2):142-146.
[14]
Akinosoglou K, Alexopoulos D. Use of antiplatelet agents in sepsis:a glimpse into the future[J]. Thromb Res, 2014, 133(2):131-138.
[15]
Lin CW, Lo S, Hsu C, et al. T-cell autophagy deficiency increases mortality and suppresses immune responses after sepsis[J]. PLoS One, 2014, 9(7):e102066.
