Comparison of therapeutic effects of prednisone combined with mycophenolate mofetil versus cyclosporin A in children with steroid-resistant nephrotic syndrome
LI Zhi-Hui, LIN Zhi, DUAN Cui-Rong, WU Tian-Hui, XUN Mai, ZHANG Yi, ZHANG Liang, DING Yun-Feng, YIN Yan
College of Pediatrics, University of South China/Children's Hospital of Hunan Province, Changsha 410007, China
Abstract：Objective To compare the therapeutic effects of prednisone combined with mycophenolate mofetil(MMF) versus cyclosporin A(CsA) in children with steroid-resistant nephrotic syndrome(SRNS).Methods The clinical data of 164 SRNS children who were treated with prednisone combined with MMF or CsA between January 2004 and December 2013 were collected, and the clinical effect of prednisone combined with MMF(MMF group, 112 children) or CsA(CsA group, 52 children) was analyzed retrospectively.Results At 1 month after treatment, the CsA group had a significantly higher remission rate than the MMF group(67.3% vs 42.9%;PPPPConclusions Prednisone combined with MMF or CsA is effective and safe for the treatment of SRNS in children, and within 3 months of treatment, CsA has a better effect than MMF.
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