小儿肥胖与支气管哮喘关联机制的研究进展

祝炼; 徐之良; 程衍杨

doi:10.7499/j.issn.1008-8830.2016.07.020

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中国当代儿科杂志 ›› 2016, Vol. 18 ›› Issue (7) : 671-676. DOI: 10.7499/j.issn.1008-8830.2016.07.020

综述

小儿肥胖与支气管哮喘关联机制的研究进展

祝炼^1,2, 徐之良¹, 程衍杨¹

作者信息 +

Research advances in association between pediatric obesity and bronchial asthma

ZHU Lian^1,2, XU Zhi-Liang¹, CHENG Yan-Yang¹

Author information +

文章历史 +

摘要

该综述介绍了肥胖引起儿童支气管哮喘在病理生理机制研究方面的进展，包括瘦素在肥胖和哮喘中的关联作用、纤溶酶原激活物抑制剂-1与肥胖和哮喘的相关性、脂联素和白细胞介素与肥胖和哮喘的相关性、神经介质对哮喘的影响作用，并特别介绍以背根感觉神经元伤感器为靶点进而阻断伤感器的信号途径抑制过敏性哮喘的最新研究。

Abstract

This review article introduces the research advances in the pathophysiological mechanism of obesity in inducing pediatric bronchial asthma, including the role of leptin in obesity and asthma, the association of plasminogen activator inhibitor-1 with obesity and asthma, the association of adiponectin and interleukins with obesity and asthma, and the influence of neurotransmitter on asthma. In particular, this article introduces the latest research on the inhibition of allergic asthma through targeting at the nociceptor of dorsal root ganglion and blocking the signaling pathway of the nociceptor.

导出引用

祝炼, 徐之良, 程衍杨. 小儿肥胖与支气管哮喘关联机制的研究进展[J]. 中国当代儿科杂志. 2016, 18(7): 671-676 https://doi.org/10.7499/j.issn.1008-8830.2016.07.020

ZHU Lian, XU Zhi-Liang, CHENG Yan-Yang. Research advances in association between pediatric obesity and bronchial asthma[J]. Chinese Journal of Contemporary Pediatrics. 2016, 18(7): 671-676 https://doi.org/10.7499/j.issn.1008-8830.2016.07.020

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