Results A total of 26 Chinese key words and 20 English key words were included. Those in the center of the co-existent knowledge map of Chinses keywords were "preterm infants", "apnea", "primary apnea", "naloxone" and "aminophylline"; while "apnea", "preterm infants" and "caffeine" located in the central place of the co-existent knowledge map of English keywords. Conclusions Methylxanthines are still the major drugs for AOP; however, aminophylline is mainly used in China, while caffeine is mainly used in foreign countries. Other drugs such as naltrexone are also used in the clinical treatment of AOP."/>
早产儿呼吸暂停药物治疗的研究现状分析
Abstract：Objective To investigate the current status of studies on drug therapy for apnea of prematurity (AOP) in the past decade in China and abroad, and to describe the research trends in the field. Methods CNKI and MEDLINE were searched with the key words "apnea of prematurity" and "treatment" for articles published in the past decade (January 2006 to December 2015). The articles were screened and the key words were extracted to establish the co-occurrence matrix. Ucinet 6.2 was used to plot the knowledge map. Results A total of 26 Chinese key words and 20 English key words were included. Those in the center of the co-existent knowledge map of Chinses keywords were "preterm infants", "apnea", "primary apnea", "naloxone" and "aminophylline"; while "apnea", "preterm infants" and "caffeine" located in the central place of the co-existent knowledge map of English keywords. Conclusions Methylxanthines are still the major drugs for AOP; however, aminophylline is mainly used in China, while caffeine is mainly used in foreign countries. Other drugs such as naltrexone are also used in the clinical treatment of AOP.
Schoen K, Yu T, Stockmann C, et al. Use of methylxanthine therapies for the treatment and prevention of apnea of prematurity[J]. Paediatr Drugs, 2014, 16(2):169-177.
Cazeneuve C, Pons G, Rey E, et al. Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults[J]. Br J Clin Pharmacol, 1994, 37(5):405-412.
Henderson-Smart D1, Steer P. Doxapram treatment for apnea in preterm infants[J]. Cochrane Database Syst Rev, 2004, (4):CD000074.
[23]
Prins SA, Pans SJ, van Weissenbruch MM, et al. Doxapram use for apnoea of prematurity in neonatal intensive care[J]. Int J Pediatr, 2013, 2013:251047.
[24]
Roll C, Horsch S. Effect of doxapram on cerebral blood flow velocity in preterm infants[J]. Neuropediatrics, 2004, 35(2):126-129.
[25]
Ten Hove CH, Vliegenthart RJ, Te Pas AB, et al. Long-term neurodevelopmental outcome after doxapram for apnea of prematurity[J]. Neonatology, 2016, 110(1):21-26.
MacDonald MG, Moss IR, Kefale GG, et al. Effect of naltrexone on apnea of prematurity and on plasma beta-endorphin-like immunoreactivity[J]. Dev Pharmacol Ther, 1986, 9(5):301-309.
