儿童巨细胞病毒感染致喘息发生的免疫学机制

朱晓华, 陈强, 李秋根, 李岚, 柯江维, 刘志强, 冉飞

中国当代儿科杂志 ›› 2016, Vol. 18 ›› Issue (9) : 831-834.

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中国当代儿科杂志 ›› 2016, Vol. 18 ›› Issue (9) : 831-834. DOI: 10.7499/j.issn.1008-8830.2016.09.009
论著·临床研究

儿童巨细胞病毒感染致喘息发生的免疫学机制

  • 朱晓华1,2, 陈强2, 李秋根3, 李岚2, 柯江维4, 刘志强4, 冉飞4
作者信息 +

Immunological mechanism of wheezing attack in children with cytomegalovirus infection

  • ZHU Xiao-Hua1,2, CHEN Qiang2, LI Qiu-Gen3, LI Lan2, KE Jiang-Wei4, LIU Zhi-Qiang4, RAN Fei4
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摘要

目的 探讨巨细胞病毒 (CMV)感染儿童喘息发作可能的免疫学发病机制。方法 选取5岁以下CMV感染喘息患儿25例,测定血清调节性T细胞 (Treg)、辅助性T细胞17 (Th17)细胞因子IL-10、IL-6、IL-17表达水平和外周血淋巴细胞亚群。20例同年龄段健康儿童作为对照组。结果 与对照组比较,CMV感染喘息组血清IL-10降低,IL-6、IL-17升高,淋巴细胞亚群NK细胞降低、CD8+T细胞、CD19+B细胞百分比升高,差异均有统计学意义。结论 CMV感染喘息儿童存在Treg/Th17失衡、细胞免疫功能紊乱,推测Treg/Th17失衡及细胞免疫功能紊乱可能是CMV感染后儿童喘息发生发展重要的免疫学发病机制。

Abstract

Objective To study the possible immunological mechanism of wheezing attack in children with cytomegalovirus (CMV) infection. Methods A total of 25 under-5-year-old children with wheezing following CMV infection were enrolled. The expression of serum regulatory T cells (Treg)/T helper 17 (Th17) cytokines interleukin (IL)-10, IL-6, and IL-17, and peripheral blood lymphocyte subsets were determined. Twenty age-matched healthy children were selected as the control group. Results The wheezing group had a significantly reduced serum IL-10 level, significantly increased IL-6 and IL-17 levels, significantly reduced levels of natural killer cells, and significantly increased levels of CD8+ T cells and CD19+ B cells, as compared with the control group. Conclusions Wheezing children with CMV infection have Treg/Th17 imbalance and cellular immune dysfunction, which may be an important immunological mechanism of the development of wheezing in children after CMV infection.

关键词

巨细胞病毒感染 / 喘息 / 免疫学机制 / 儿童

Key words

Cytomegalovirus infection / Wheezing / Immunological mechanism / Child

引用本文

导出引用
朱晓华, 陈强, 李秋根, 李岚, 柯江维, 刘志强, 冉飞. 儿童巨细胞病毒感染致喘息发生的免疫学机制[J]. 中国当代儿科杂志. 2016, 18(9): 831-834 https://doi.org/10.7499/j.issn.1008-8830.2016.09.009
ZHU Xiao-Hua, CHEN Qiang, LI Qiu-Gen, LI Lan, KE Jiang-Wei, LIU Zhi-Qiang, RAN Fei. Immunological mechanism of wheezing attack in children with cytomegalovirus infection[J]. Chinese Journal of Contemporary Pediatrics. 2016, 18(9): 831-834 https://doi.org/10.7499/j.issn.1008-8830.2016.09.009

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