Abstract：Objective To study the effect of obesity on the treatment outcome of asthma predictive index (API) -positive infants and young children with wheezing. Methods A total of 208 API-positive infants and young children with wheezing were enrolled. According to the Kaup index, the patients were divided into an obese group (n=93) and a non-obese group (n=115). The patients were given multimodality therapy in an acute episode of wheezing and aerosol inhalation of inhaled corticosteroid (ICS) budesonide suspension in the remission stage. The dose of ICS was adjusted according to clinical control. The patients were treated for 6 months, and were followed up at 2 weeks after treatment and once per month afterwards. Results At 2 weeks and 1 month after treatment, the obese group had significantly lower remission rates of clinical symptoms than the non-obese group (35.5%/75.3% vs 53.0%/87.8%; P P Conclusions Obesity can inhibit the response to ICS treatment in API-positive infants and young children with wheezing.
CHEN Bo,FENG Shuai,YIN Xiao-Wen. Effect of obesity on treatment outcome of asthma predictive index-positive infants and young children with wheezing[J]. CJCP, 2016, 18(10): 991-994.
Visness CM, London SJ, Daniels JL. Association of childhood obesity with atopic and nonatopic asthma: results from the National Health and Nutrition Examination Survey 1999-2006.[J]. J Asthma, 2010, 47(7): 822-829.
Vo P, Bair-Merritt M, Camargo CA. The potential role of vitamin D in the link between obesity and asthma severity/control in children[J]. Expert Rev Respir Med, 2015, 9(3): 309-325.
Pedersen SE, Hurd SS, Lemanske RF Jr, et al; Global Initiative for Asthma. Global strategy for the diagnosis and management of asthma in children 5 years and younger[J]. Pediatr Pulmonol, 2011, 46(1): 1-17.
Forno E, Lescher R, Strunk R, et al; Childhood Asthma Management Program Research Group. Decreased response to inhaled steroids in overweight and obese asthmatic children[J]. J Allergy Clin Immunol, 2011, 127(3): 741-749.
[14]
Rasmussen F, Hancox RJ. Mechanisms of obesity in asthma[J]. Curr Opin Allergy Clin Immunol, 2014, 14(1): 35-43.
