Abstract：A two-month-old boy visited the hospital due to unexpected cutaneous purpura and thrombocytopenia for 2 days. The physical examination revealed a purple mass on the back. The soft tissue color Doppler ultrasound showed rich blood signals in the tissue, and the results of bone marrow puncture indicated an increased number of megakaryocytes. After the treatment with hormone and gamma globulin, the platelet count rapidly increased and maintained at a normal level. Meanwhile, the boy was given oral administration of propranolol. He was followed up for 4 months and the volume of the mass on the back was reduced significantly. He had a definite diagnosis of hemangioma and immune thrombocytopenia. As for the patients with hemangioma complicated by thrombocytopenia, knowledge of Kasabach-Merritt syndrome should be enhanced and there should be a clarification of the association between thrombocytopenia and hemangioma. There should also be an alertness for thrombocytopenia of other causes.
Jeong JO,Byun J,Jeon ES,et al.Improved expression by cytomegalovirus promoter/enhancer and bahavior of vascular endothelial growth factor gene after myocardial injection of naked DNA[J].Exp Mol Med,2002,34(4):278-284.
Yuan SM,Shen WM,Chen HN,et al.Kasabach-Merritt phenomenon in Chinese children:report of 19 cases and brief review of literature[J].Int J Clin Exp Med,2015,8(6):10006-10010.
[14]
Wang P,Zhou W,Tao L,et al.Clinical analysis of Kasabach-Merritt syndrome in 17 neonates[J].BMC Pediatr,2014,14:146.
[15]
Kwok-Williams M,Perez Z,Squire R,et al.Radiotherapy for life-threatening mediastinal haemangioma with Kasabach-Merritt syndrome[J].Pediatr Blood Cancer,2007,49(5):739-744.
[16]
刘霞.血管瘤血小板减少综合症2例[J].中国当代儿科杂志,2000,2(4):274.
[17]
O'Rafferty C,O'Regan GM,Irvine AD,et al.Recent advances in the pathobiology and management of Kasabach-Merritt phenomenon[J].Br J Haematol,2015,171(1):38-51.
