Association between IL-19 gene polymorphisms and hepatitis B virus susceptibility in children
FAN Jie1, MU Li-Hong1, ZHOU Li1, HUANG Xin1, HUANG Yan-Feng2
School of Public Health and Management, Chongqing Medical University/Research Center for Medicine and Social Development/Innovation Center for Social Risk Governance in Health, Chongqing 400016, China
Abstract：Objective To study the association between the single nucleotide polymorphisms (SNP) of interleukin (IL)-19 and susceptibility to hepatitis B virus (HBV) infection in children. Methods A case-control study was performed, and 136 children with positive HBsAg (case group) and 297 healthy children with negative HBsAg (control group) were enrolled. PCR and DNA sequencing were used for genotyping. Results There were significant differences in the frequencies of genotypes of IL-19 rs1798 between the case and control groups. The case group also had a significantly higher proportion of children with CG genotype than the control group (P < 0.05). There were significant differences in the frequencies of genotypes and alleles of IL-19 rs2243191 between the HBV infection and non-infection groups among children who born to HBV-positive mothers. The infection group had significantly higher proportions of children with TC and CC genotypes and C allele than the non-infection group (P < 0.05). Conclusions The SNP of IL-19 rs1798 may be associated with susceptibility to hepatitis B in children, and the SNP of IL-19 rs2243191 may be associated with susceptibility to breakthrough HBV infection in children at a high risk of HBV infection.
FAN Jie,MU Li-Hong,ZHOU Li et al. Association between IL-19 gene polymorphisms and hepatitis B virus susceptibility in children[J]. CJCP, 2016, 18(12): 1277-1281.
Motavaf M, Safari S, Alavian SM. Interleukin 18 gene promoter polymorphisms and susceptibility to chronic hepatitis B infection: a review study[J]. Hepat Mon, 2014, 14(7): e19879.
[6]
Wu L, Chen L, Zhou L, et al. Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population[J]. Hepat Mon, 2011, 11(6): 469-474.
Liao YC, Liang WG, Chen FW, et al. IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha[J]. J Immunol, 2002, 169(8): 4288-4297.
Zhang PA, Wu JM, Li Y, et al. Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population[J]. World J Gastroenterol, 2005, 11(11): 1594-1598.
[12]
Miyazoe S, Hamasaki K, Nakata K, et al. Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus[J]. Am J Gastroenterol, 2002, 97(8): 2086-2092.
[13]
Shin HD, Park BL, Kim LH, et al. Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma[J]. Hum Mol Genet, 2003, 12(8): 901-906.
[14]
Zhu QR, Ge YL, Gu SQ, et al. Relationship between cytokines gene polymorphism and susceptibility to hepatitis B virus intrauterine infection[J]. Chin Med J (Engl), 2005, 118(19): 1604-1609.
[15]
Moudi B, Heidari Z, Mahmoudzadeh-Sagheb H, et al. Association between IL-10 gene promoter polymorphisms (-592 A/C,-819 T/C,-1082 A/G) and susceptibility to HBV infection in an Iranian population[J]. Hepat Mon, 2016, 16(2): e32427.
[16]
Truelove AL, Oleksyk TK, Shrestha S, et al. Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome[J]. Int J Immunogenet, 2008, 35(3): 255-264.
[17]
Ryckman KK, Fielding K, Hill AV, et al. Host genetic factors and vaccine-induced immunity to HBV infection: haplotype analysis[J]. PLoS One, 2010, 5(8): e12273.
[18]
Yamamoto-Furusho JK, Álvarez-León E, Fragoso JM, et al. Protective role of interleukin-19 gene polymorphisms in patients with ulcerative colitis[J]. Hum Immunol, 2011, 72(11): 1029-1032.
[19]
Shao ZJ, Zhang L, Xu JQ, et al. Mother-to-infant transmission of hepatitis B virus: a Chinese experience[J]. J Med Virol, 2011, 83(5): 791-795.
[20]
Yucesoy B, Talzhanov Y, Johnson VJ, et al. Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations[J]. Vaccine, 2013, 31(46): 5381-5391.
