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特应性体质对毛细支气管炎患儿血清糖皮质激素受体水平的影响
姚欢银, 刘伟荣, 章杭湖, 李华浚, 王小仙, 刘淑梅, 陈啸洪
中国当代儿科杂志 ›› 2017, Vol. 19 ›› Issue (2) : 163-166.
PDF(1222 KB)
PDF(1222 KB)
特应性体质对毛细支气管炎患儿血清糖皮质激素受体水平的影响
Effect of atopy on serum glucocorticoid receptor levels in children with bronchiolitis
目的 探讨特应性体质 （简称特应质）对毛细支气管炎 （简称毛支）患儿糖皮质激素受体 （GR）表达的影响。方法 采用ELISA法测定和比较毛支组 （77例，包括34例特应质患儿）和肺炎组 （68例）患儿血清中GRα、GRβ水平的变化。38例同期住院的非感染性小儿外科术前患儿，且无特应性及过敏性疾病家族史的患儿作为对照组。结果 与对照组比较，毛支组和肺炎组中血清GRα、GRβ水平均明显升高 （P < 0.01）；毛支组血清GRα、GRβ水平高于肺炎组 （P < 0.01）。毛支组GRα/GRβ比值较对照组和肺炎组明显升高 （P < 0.01）。毛支组特应质和非特应质患儿血清GRα、GRβ水平与对照组比较均明显升高 （P < 0.01）；毛支组非特应质患儿GRβ水平明显高于特应质患儿 （P < 0.01）；毛支组特应质患儿GRα/GRβ比值较对照组和毛支组非特应质患儿明显升高 （P < 0.01）。结论 毛支患儿血清GRα、GRβ表达水平增强；特应质毛支患儿表现为GRα/GRβ比值增加，提示特应质毛支患儿对糖皮质激素有较高的敏感性。
Objective To investigate the effect of atopy on the expression of glucocorticoid receptors in children with bronchiolitis. Methods ELISA was used to measure the changes in the serum levels of glucocorticoid receptor α (GRα) and glucocorticoid receptor β (GRβ) in the bronchiolitis group (77 children, including 34 children with atopy) and pneumonia group (68 children). Thirty-eight children who were prepared to undergo surgeries for non-infectious diseases and had no atopy or family history of allergic diseases were enrolled as the control group. Results The bronchiolitis group and the pneumonia group had significant increases in the serum levels of GRα and GRβ compared with the control group (P < 0.01), and the bronchiolitis group had significant increases in these levels compared with the pneumonia group (P < 0.01). Compared with the control group and the pneumonia group, the bronchiolitis group had a significant increase in the GRα/GRβ ratio (P < 0.01). Compared with the control group, the children with or without atopy in the bronchiolitis group had significant increases in the serum levels of GRα and GRβ (P < 0.01). The non-atopic children in the bronchiolitis group had a significant increase in the serum level of GRβ compared with the atopic children (P < 0.01). The atopic children in the bronchiolitis group had a significant increase in the GRα/GRβ ratio compared with the control group and non-atopic children in the bronchiolitis group (P < 0.01). Conclusions Children with bronchiolitis have increased serum levels of GRα and GRβ. The children with atopy have an increased GRα/GRβ ratio, suggesting that the atopic children with bronchiolitis are highly sensitive to glucocorticoids.
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浙江省医药卫生一般研究计划A类（2015KYA219）。
