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脑源性神经营养因子与儿童哮喘严重程度的关系
Association between brain-derived neurotrophic factor and severity of asthma in children
目的 探讨血清脑源性神经营养因子 （BDNF）水平与哮喘患儿病情严重程度的关系。方法 选取60例哮喘急性发作期儿童 （轻度组18例、中度组25例、重度组17例）及60例健康体检儿童作为研究对象，采用酶联免疫吸附法 （ELISA）检测血清BDNF，分析BDNF水平与哮喘严重程度的关系。结果 哮喘急性发作组及症状缓解组的BDNF水平均高于对照组，以急性发作组最高 （P < 0.05）；治疗后处于缓解期时，BDNF水平较发作期明显降低 （P < 0.05）。发作期哮喘患儿病情严重程度不同，其血清BDNF水平不同：轻度组最低、重度组最高，差异有统计学意义 （P < 0.05）。结论 BDNF可能在儿童哮喘的发病机制中发挥一定的作用，并且与病情严重程度相关。
Objective To investigate the association between the serum level of brain-derived neurotrophic factor (BDNF) and the severity of asthma in children. Methods A total of 60 children with acute exacerbation of asthma were enrolled and divided according to the severity of the disease into mild group (n=18), moderate group (n=25), and severe group (n=17). Sixty healthy children were enrolled as controls. ELISA was used to measure the serum BDNF level in each group and the association between serum BDNF level and the severity of asthma was analyzed. Results The asthmatic children at the acute exacerbation and remission stages had significantly higher serum BDNF levels than healthy controls (P < 0.05). The serum BDNF level was significantly reduced in the remission stage compared with that in the acute exacerbation stage in asthmatic children (P < 0.05). The children with varying degrees of severity at the acute exacerbation stage had different serum BDNF levels: the severe group had the highest serum BDNF level and the mild group had the lowest level (P < 0.05). Conclusions BDNF may play an important role in the pathogenesis of childhood asthma and is related to the severity of the disease.
血清脑源性神经营养因子 / 哮喘 / 严重程度 / 儿童
Serum brain-derived neurotrophic factor / Asthma / Severity / Child
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国家自然科学基金（21567024）。
