Abstract：Objective To investigate the status of pubertal development in children born with assisted reproductive technology (ART). Methods A retrospective analysis was performed on the pubertal development data of children born with ART in Peking University Third Hospital from 1994 to 2003 (ART group). The data in the cross-sectional study "Reports on the Physical Fitness and Health Research of Chinese School Students in 2010" were used as a control. The age at menarche and the age at spermarche were compared between the two groups. The status of pubertal development in the overweight and obese children in the ART group was evaluated to investigate the correlation between pubertal development and body mass index (BMI). Results A total of 200 children born with ART were enrolled in this study, and 72 of them (41 males and 31 females) completed the survey (response rate=36.0%). In the ART group, the mean age at spermarche and the mean age at menarche were 13.9 years (95%CI:13.7-14.3 years) and 12.2 years (95%CI:11.8-12.6 years), respectively. There were no significant differences in the age at spermarche and the age at menarche between the ART and control groups (P > 0.05). In the ART group, there were no significant differences in the age at spermarche and the age at menarche between the overweight and obese children and the normal weight children (P > 0.05). There were also no significant differences in overweight rate and obesity rate between the children in the ART group and the adolescents in Beijing (P > 0.05). In the ART group, there was no significant correlation between the age at spermarche or menarche and BMI (P > 0.05). Conclusions No delayed or precocious puberty is observed in children born with ART. This is consistent with the normal control data. And there is no significant correlation between pubertal development and BMI in children born with ART.
LIU Zi-Yuan,WANG Xin-Li,HAN Tong-Yan et al. A survey of pubertal development in children born with assisted reproductive technology[J]. CJCP, 2017, 19(6): 646-651.
Manning M, Lissens W, Bonduelle M, et al. Study of DNA-methylation patterns at chromosome 15q11-q13 in children born after ICSI reveals no imprinting defects[J]. Mol Hum Reprod, 2000, 6(11):1049-1053.
[2]
Bulcao Macedo D, Nahime Brito V, Latronico AC. New causes of central precocious puberty:the role of genetic factors[J]. Neuroendocrinology, 2014, 100(1):1-8.
[3]
Fisher-Jeffes LJ, Banerjee I, Sutcliffe AG. Parents' concerns regarding their ART children[J]. Reproduction, 2006, 131(2):389-394.
[4]
Song Y, Ma J, Wang HJ, et al. Trends of age at menarche and association with body mass index in Chinese school-aged girls, 1985-2010[J]. J Pediatr, 2014, 165(6):1172-1177.
[5]
Song Y, Ma J, Wang HJ, et al. Age at spermarche:15-year trend and its association with body mass index in Chinese school-aged boys[J]. Pediatr Obes, 2016, 11(5):369-374.
[6]
World Health Organization. WHO Reference 2007 SPSS macro package[EB/OL]. (June 19, 2014).
Uh KJ, Park CH, Choi KH, et al. Analysis of imprinted IGF2/H19 gene methylation and expression in normal fertilized and parthenogenetic embryonic stem cells of pigs[J]. Anim Reprod Sci, 2014, 147(1-2):47-55.
[11]
Perry JR, Day F, Elks CE, et al. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche[J]. Nature, 2014, 514(7520):92-97.
Beydoun HA, Sicignano N, Beydoun MA, et al. Pubertal development of the first cohort of young adults conceived by in vitro fertilization in the United States[J]. Fertil Steril, 2011, 95(2):528-533.
[14]
Kleber M, Schwarz A, Reinehr T. Obesity in children and adolescents:relationship to growth, pubarche, menarche, and voice break[J]. J Pediatr Endocrinol Metab, 2011, 24(3-4):125-130.
[15]
Ceelen M, van Weissenbruch MM, Vermeiden JP, et al. Pubertal development in children and adolescents born after IVF and spontaneous conception[J]. Hum Reprod, 2008, 23(12):2791-2798.
[16]
Rojas-Marcos PM, David R, Kohn B. Hormonal effects in infants conceived by assisted reproductive technology[J]. Pediatrics, 2005, 116(1):190-194.
[17]
Belva F, Roelants M, Painter R, et al. Pubertal development in ICSI children[J]. Hum Reprod, 2012, 27(4):1156-1161.
[18]
Neville KA, Walker JL. Precocious pubarche is associated with SGA, prematurity, weight gain, and obesity[J]. Arch Dis Child, 2005, 90(3):258-261.
