Abstract：Objective To investigate the association between the genetic polymorphism of IL-6 C-572G and susceptibility to spontaneous preterm birth (SPTB). Methods The subjects were from Beijing and the surrounding areas of Beijing. This case-control study enrolled 569 SPTB infants, including 56 extremely preterm ( +6 weeks of gestation) and 347 moderate to late preterm infants (32 to 36+6 weeks of gestation). A total of 673 term infants were enrolled as the control group. The latest Sequenom MassARRAY®SNP detection technique was used for the typing of single nucleotide polymorphism of IL-6 C-572G. Results Compared with the CC genotypes, the IL-6 C-572G G-positive genotype (CG+GG genotype) was signifcantly associated with an increased susceptibility to moderate to late SPTB (OR=1.35, 95%CI:1.01-1.80, P=0.04). Conclusions Among the Chinese population, IL-6 C-572G polymorphism is associated with susceptibility to moderate to late SPTB.
Ryckman KK, Morken NH, White MJ, et al. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth[J]. PLoS One, 2010, 5(2):e9040.
[2]
Hollegaard MV, Grove J, Thorsen P, et al. Polymorphisms in the tumor necrosis factor alpha and interleukin 1-beta promoters with possible gene regulatory functions increase the risk of preterm birth[J]. Acta Obstet Gynecol Scand, 2008, 87(12):1285-1290.
[3]
Gomez-Lopez N, Laresgoiti-Servitje E, Olson DM, et al. The role of chemokines in term and premature rupture of the fetal membranes:a review[J]. Biol Reprod, 2010, 82(5):809-814.
[4]
Sun GQ, Wu GD, Meng Y, et al. IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population[J]. Genet Mol Res, 2014, 13(3):7718-7724.
[5]
Velez DR, Fortunato SJ, Williams SM, et al. Interleukin-6(IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth[J]. Hum Mol Genet, 2008, 17(11):1619-1630.
[6]
World Health Orgnization. Preterm birth[EB/OL]. (November 2016).
Lee SY, Buhimschi IA, Dulay AT, et al. IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes[J]. J Immunol, 2011, 186(5):3226-3236.
[10]
Naugler WE, Karin M. The wolf in sheep's clothing:the role of interleukin-6 in immunity, inflammation and cancer[J]. Trends Mol Med, 2008, 14(3):109-119.
[11]
Yao J, Feng XW, Yu XB, et al. Recipient IL-6-572C/G genotype is associated with reduced incidence of acute rejection following liver transplantation[J]. J Int Med Res, 2013, 41(2):356-364.
[12]
Goldenberg RL, Culhane JF, Iams JD, et al. Epidemiology and causes of preterm birth[J]. Lancet, 2008, 371(9606):75-84.
[13]
Prins JR, Gomez-Lopez N, Robertson SA. Interleukin-6 in pregnancy and gestational disorders[J]. J Reprod Immunol, 2012, 95(1-2):1-14.
[14]
Zhao N, Liu HJ, Sun YY, et al. Role of interleukin-6 polymorphisms in the development of allergic rhinitis[J]. Genet Mol Res, 2016, 15(1):14-17.
[15]
Taylor BD, Holzman CB, Fichorova RN, et al. Inflammation biomarkers in vaginal fluid and preterm delivery[J]. Hum Reprod, 2013, 28(4):942-952.
