Abstract：Objective To examine serum 25-hydroxyvitamin D levels in children with tic disorders (TD) and to explore the relationship between vitamin D level and TD. Methods One hundred and thirty-two children who were diagnosed with TD between November 2016 and May 2017 were enrolled as the TD group, including 8 cases of Tourette syndrome, 32 cases of chronic TD, and 92 cases of transient TD. One hundred and forty-four healthy children served as the control group. Peripheral venous blood samples were collected from each child. Serum levels of 25-hydroxyvitamin D were measured using HPLC-MS/MS. The categories of vitamin D status based on serum 25-hydroxyvitamin D level included:normal ( > 30 ng/mL), insufficiency (10-30 ng/mL) and deficiency ( < 10 ng/mL). Results Mean serum level of 25-hydroxyvitamin D in the TD group was significantly lower than that in the control group (P < 0.01). The rate of vitamin D insufficiency or deficiency in the TD group was significantly higher than in the control group (P < 0.01). Mean serum level of 25-hydroxyvitamin D in the transient tic group was higher than in the TS group (P < 0.05). Conclusions Vitamin D insufficiency or deficiency might be associated with the development of TD, and the level of serum 25-hydroxyvitamin D might be related to the classification of TD.
Centers for Disease Control and Prevention (CDC). Prevalence of diagnosed Tourette syndrome in persons aged 6-17 years-United States, 2007[J]. MMWR Morb Mortal Wkly Rep, 2009, 58(21):581-585.
[3]
Bitsko RH, Holbrook JR, Visser SN, et al. A national profile of Tourette syndrome, 2011-2012[J]. J Dev Behav Pediatr, 2014, 35(5):317-322.
[4]
Knight T, Steeves T, Day L, et al. Prevalence of tic disorders:a systematic review and meta-analysis[J]. Pediatr Neurol, 2012, 47(2):77-90.
[5]
Godar SC, Mosher LJ, Di Giovanni G, et al. Animal models of tic disorders:a translational perspective[J]. J Neurosci Methods, 2014, 238:54-69.
[6]
Cui X, Pelekanos M, Liu PY, et al. The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain[J]. Neuroscience, 2013, 236:77-87.
[7]
Liu Y, Li YW, Tang YL, et al. Vitamin D:preventive and therapeutic potential in Parkinson's disease[J]. Curr Drug Metab, 2013, 14(9):989-993.
[8]
Canadian Paediatric Society. Vitamin D supplementation:recommendations for Canadian mothers and infants[J]. Paediatr Child Health, 2007, 12(7):583-589.
[9]
Groves NJ, Burne THJ. The impact of vitamin D deficiency on neurogenesis in the adult brain[J]. Neural Regen Res, 2017, 12(3):393-394.
[10]
Eyles DW, Smith S, Kinobe R, et al. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain[J]. J Chem Neuroanat, 2005, 29(1):21-30.
[11]
Cui X, Pertile R, Liu P, et al. Vitamin D regulates tyrosine hydroxylase expression:N-cadherin a possible mediator[J]. Neuroscience, 2015, 304:90-100.
[12]
Kočovská E, Fernell E, Billstedt E, et al. Vitamin D and autism:clinical review[J]. Res Dev Disabil, 2012, 33(5):1541-1550.
[13]
Hawes JE, Tesic D, Whitehouse AJ, et al. Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse[J]. Behav Brain Res, 2015, 286:192-200.
[14]
Kesby JP, Turner KM, Alexander S, et al. Developmental vitamin D deficiency alters multiple neurotransmitter systems in the neonatal rat brain[J]. Int J Dev Neurosci, 2017, 62:1-7.
[15]
Pappas SS, Leventhal DK, Albin RL, et al. Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits[J]. Curr Top Dev Biol, 2014, 109:97-169.
[16]
McCairn KW, Iriki A, Isoda M. Global dysrhythmia of cerebro-basal ganglia-cerebellar networks underlies motor tics following striatal disinhibition[J]. J Neurosci, 2013, 33(2):697-708.
[17]
Lerner A, Bagic A, Simmons JM, et al. Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome[J]. Brain, 2012, 135(Pt 6):1926-1936.
[18]
Bronfeld M, Yael D, Belelovsky K, et al. Motor tics evoked by striatal disinhibition in the rat[J]. Front Syst Neurosci, 2013, 7:50.
[19]
Sikoglu EM, Navarro AA, Starr D, et al. Vitamin D3 supplemental treatment for mania in youth with bipolar spectrum disorders[J]. J Child Adolesc Psychopharmacol, 2015, 25(5):415-424.
