NUDT15基因型对儿童急性淋巴细胞白血病6-MP个体化治疗的影响

贺晶; 刘伶

doi:10.7499/j.issn.1008-8830.2019.01.018

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中国当代儿科杂志 ›› 2019, Vol. 21 ›› Issue (1) : 100-104. DOI: 10.7499/j.issn.1008-8830.2019.01.018

综述

NUDT15基因型对儿童急性淋巴细胞白血病6-MP个体化治疗的影响

贺晶, 刘伶

作者信息 +

Significance of NUDT15 gene in individualized treatment with 6-mercaptopurine in children with acute lymphoblastic leukemia

HE Jing, LIU Ling

Author information +

文章历史 +

摘要

6-巯基嘌呤（6-MP）是急性淋巴细胞白血病（ALL）维持治疗阶段的重要药物，其副作用包括肝毒性和骨髓抑制，不同个体对6-MP的耐受差异较大，6-MP治疗需个体化。巯嘌呤甲基转移酶（TPMT）活性缺乏与6-MP不耐受具有相关性。但亚洲患者TPMT等位基因的突变频率较低。近来发现存在NUDT15基因突变的ALL患者6-MP耐受剂量低于常规剂量。该文就NUDT15基因型对ALL患儿6-MP个体化治疗的影响进行综述。

Abstract

As an important drug during maintenance treatment of acute lymphoblastic leukemia (ALL), 6-mercaptopurine (6-MP) has several side effects, including hepatotoxicity and bone marrow suppression. Since its tolerability varies from person to person, 6-MP treatment should be individualized. The deficiency of thiopurine methyltransferase (TPMT) enzyme activity is associated with 6-MP intolerance. There is a lower frequency of mutation in TPMT alleles among Asian patients. Recent studies have shown that in ALL patients with NUDT15 gene mutation, the maximum tolerated dose of 6-MP is lower than the conventional dose. The article reviews the significance of NUDT15 gene in individualized treatment with 6-MP in children with ALL.

导出引用

贺晶, 刘伶. NUDT15基因型对儿童急性淋巴细胞白血病6-MP个体化治疗的影响[J]. 中国当代儿科杂志. 2019, 21(1): 100-104 https://doi.org/10.7499/j.issn.1008-8830.2019.01.018

HE Jing, LIU Ling. Significance of NUDT15 gene in individualized treatment with 6-mercaptopurine in children with acute lymphoblastic leukemia[J]. Chinese Journal of Contemporary Pediatrics. 2019, 21(1): 100-104 https://doi.org/10.7499/j.issn.1008-8830.2019.01.018

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