A multicenter epidemiological investigation of brain injury in hospitalized preterm infants in Anhui, China
ZHANG Jian1, LIU Guang-Hui1, ZHAO Yu-Wei1, WANG Hui-Qin2, MAO Shuang-Gen3, MAO Guo-Shun4, XI Kang-Ming5, WANG Li-Li6, ZHANG Chuan-Long7, GAO Cheng-Ju8, HUANG Dao-Dan9
Department of Neonatology, Anhui Provincial Children's Hospital, Hefei 230051, China
Abstract：Objective To investigate the risk factors for brain injury in preterm infants by a multicenter epidemiological investigation of brain injury in hospitalized preterm infants in Anhui, China. Methods Preterm infants who were hospitalized in the department of neonatology in 9 hospitals of Anhui Neonatal Collaboration Network between January 2016 and January 2017 were enrolled as subjects. The data of maternal pregnancy and clinical data of preterm infants were collected, and the logistic regression model was used to analyze the risk factors for brain injury in preterm infants. Results A total of 3 378 preterm infants were enrolled. Of the 3 378 preterm infants, 798 (23.56%) had periventricular-intraventricular hemorrhage (PVH-IVH), and 88 (2.60%) had periventricular leukomalacia (PVL). Intrauterine distress, anemia, hypoglycemia and necrotizing enterocolitis (NEC) were risk factors for PVH-IVH (OR=1.310, 1.591, 1.835, and 3.310 respectively; P < 0.05), while a higher gestational age was a protective factor against PVH-IVH (OR=0.671, P < 0.05). PVH-IVH, NEC and mechanical ventilation were risk factors for PVL (OR=4.017, 3.018, and 2.166 respectively; P < 0.05), and female sex and use of pulmonary surfactant were protective factors against PVL (OR=0.514 and 0.418 respectively; P < 0.05). Conclusions Asphyxia/anoxia, infection/inflammation, mechanical ventilation, anemia and hypoglycemia may increase the risk of brain injury in preterm infants.
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