Abstract：Objective To study the clinical effect of white noise combined with glucose in reducing the procedural pain of retinopathy screening in preterm infants. Methods A total of 396 preterm infants with a gestational age of 28-34 weeks and a birth weight of ≤ 2 000 g were randomly divided into 4 groups according to the intervention method for reducing pain in retinopathy screening:control group with 100 infants (no white noise or glucose intervention), white noise group with 96 infants, glucose group with 98 infants and white noise + glucose group with 102 infants. The Premature Infant Pain Profile (PIPP) was used to determine pain score during retinopathy screening, and the four groups were compared in terms of PIPP score before and after retinopathy screening. Results There were no significant differences in PIPP score, heart rate and blood oxygen saturation between the four groups at 3 minutes before screening (P > 0.05). At 1 and 5 minutes after screening, the white noise, glucose and white noise + glucose groups had significantly lower heart rate and PIPP score but significantly higher blood oxygen saturation than the control group (P < 0.05).The white noise + glucose group had significantly lower heart rate and PIPP score but significantly higher blood oxygen saturation than the white noise and glucose groups (P < 0.05). Conclusions White noise combined with glucose can reduce the procedural pain of retionopathy screening and keep vital signs stable in preterm infants.
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