中国当代儿科杂志
  中文版
  English Version
  ISSN 2096-9228(online)
ISSN 1008-8830(print)
CN 43-1301/R
 
中国当代儿科杂志  2020, Vol. 22 Issue (8): 887-891    DOI:10.7499/j.issn.1008-8830.2002191
论著·临床研究 最新目录| 下期目录| 过刊浏览| 高级检索 |
血清降钙素原联合可溶性髓样细胞触发受体-1对儿童细菌性腹泻和病毒性腹泻的鉴别诊断价值
杨雪利, 白静, 宋紫霞, 张娟, 梁敏
川北医学院第二临床医学院南充市中心医院儿科, 四川 南充 637000
Value of serum procalcitonin combined with soluble triggering receptor expressed on myeloid cells-1 in the differential diagnosis of bacterial and viral diarrhea in children
YANG Xue-Li, BAI Jing, SONG Zi-Xia, ZHANG Juan, LIANG Min
Department of Pediatrics, Nanchong Central Hospital, Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan 637000, China
全文: PDF (1447 KB)   HTML(112)
输出: BibTeX | EndNote (RIS)      背景资料
摘要 

目的 探讨血清降钙素原(PCT)联合可溶性髓样细胞触发受体-1(STREM-1)对儿童细菌性腹泻与病毒性腹泻的鉴别价值。方法 回顾性分析2018年2月至2019年5月入院接受治疗的细菌感染性腹泻患儿73例(细菌组)、病毒感染性腹泻患儿68例(病毒组)的临床资料。采用受试者工作特征(ROC)曲线分析血清PCT和STREM-1对细菌感染性腹泻与病毒感染性腹泻的诊断效能。结果 细菌组患儿粪便红细胞及脓液检出率分别为79%、51%,高于病毒组的43%、19%(P < 0.05)。细菌组患儿血清PCT和STREM-1水平均显著高于病毒组(P < 0.05)。ROC分析结果显示,血清PCT、STREM-1对儿童细菌性感染与病毒性感染腹泻鉴别的截断值分别为0.97?ng/mL、15.66?ng/mL;曲线下面积(AUC)分别为0.792、0.889。二者联合诊断的AUC为0.955,其诊断效能高于两单独指标(P < 0.05)。结论 细菌性腹泻患儿血清PCT和STREM-1水平高于病毒性腹泻患儿;血清PCT和STREM-1均可作为儿童细菌性腹泻与病毒性腹泻的鉴别指标,二者联合检测可提高鉴别诊断效能。

服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
杨雪利
白静
宋紫霞
张娟
梁敏
关键词 感染性腹泻降钙素原可溶性髓样细胞触发受体-1鉴别诊断儿童    
Abstract:Objective To study the value of serum procalcitonin (PCT) combined with soluble triggering receptor expressed on myeloid cells-1 (STREM-1) in the differential diagnosis of bacterial diarrhea and viral diarrhea in children. Methods A retrospective analysis was performed on the medical data of 73 children with bacterial infectious diarrhea (bacteria group) and 68 children with viral infectious diarrhea (virus group) who were treated from February 2018 to May 2019. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficacy of serum PCT and STREM-1 for bacterial infectious diarrhea and viral infectious diarrhea. Results Compared with the virus group, the bacteria group had significantly higher detection rates of fecal red blood cells (79% vs 43%, P < 0.05) and pus (51% vs 19%, P < 0.05), as well as significantly higher serum levels of PCT and STREM-1 (P < 0.05). The ROC curve analysis showed that in the differential diagnosis of bacterial infectious diarrhea and viral infectious diarrhea, serum PCT had a cut-off value of 0.97 ng/mL and an area under the ROC curve (AUC) of 0.792, and STREM-1 had a cut-off value of 15.66 ng/mL and an AUC of 0.889. Serum PCT combined with STREM-1 had an AUC of 0.955, which was significantly higher than that of each index alone (P < 0.05). Conclusions Children with bacterial diarrhea have increased serum levels of PCT and STREM-1 than those with viral diarrhea. Both serum PCT and STREM-1 can be used as the indices for the differential diagnosis of bacterial diarrhea and viral diarrhea in children, and the combined measurement of PCT and STREM-1 can improve the efficiency of differential diagnosis.
Key wordsInfectious diarrhea    Procalcitonin    Soluble triggering receptor expressed on myeloid cells-1    Differential diagnosis    Child   
收稿日期: 2020-02-29     
作者简介: 杨雪利,女,本科,主治医师。Email:rbcghw@163.com。
引用本文:   
杨雪利,白静,宋紫霞等. 血清降钙素原联合可溶性髓样细胞触发受体-1对儿童细菌性腹泻和病毒性腹泻的鉴别诊断价值[J]. 中国当代儿科杂志, 2020, 22(8): 887-891.
YANG Xue-Li,BAI Jing,SONG Zi-Xia et al. Value of serum procalcitonin combined with soluble triggering receptor expressed on myeloid cells-1 in the differential diagnosis of bacterial and viral diarrhea in children[J]. CJCP, 2020, 22(8): 887-891.
链接本文:  
http://www.zgddek.com/CN/10.7499/j.issn.1008-8830.2002191     或     http://www.zgddek.com/CN/Y2020/V22/I8/887
版权所有 ©《中国当代儿科杂志》编辑部
地址:湖南省长沙市湘雅路87号 电话:0731-84327402  传真:0731-84327922 E-mail: cjcp1999@csu.edu.cn 
本系统由北京玛格泰克科技发展有限公司设计开发 技术支持:support@magtech.com.cn
湘ICP备17021739号-4